The Apolipoprotein E Antagonistic Pleiotropy Hypothesis : Review and Recommendations
Joint Authors
Han, S. Duke
Tuminello, Elizabeth R.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Research on apolipoprotein E (APOE) has consistently revealed a relationship between the gene's ε4 allele and risk for development of Alzheimer's disease (AD).
However, research with younger populations of ε4 carriers has suggested that the APOE ε4 allele may in fact be beneficial in earlier ages and may only confer risk of cognitive decline later in life.
Accordingly, we and others have proposed that APOE may represent an example of antagonistic pleiotropy.
Antagonistic pleiotropy is an evolutionary biology concept that proposes certain genes or alleles that may differentially impact fitness during different life stages.
We critically review this hypothesis in light of new research of the impact of APOE on cognition and neural integrity across the lifespan.
We provide recommendations for the revision of the antagonistic pleiotropy hypothesis of APOE and suggest important avenues for future research in this area.
American Psychological Association (APA)
Tuminello, Elizabeth R.& Han, S. Duke. 2011. The Apolipoprotein E Antagonistic Pleiotropy Hypothesis : Review and Recommendations. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-493730
Modern Language Association (MLA)
Tuminello, Elizabeth R.& Han, S. Duke. The Apolipoprotein E Antagonistic Pleiotropy Hypothesis : Review and Recommendations. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-493730
American Medical Association (AMA)
Tuminello, Elizabeth R.& Han, S. Duke. The Apolipoprotein E Antagonistic Pleiotropy Hypothesis : Review and Recommendations. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-493730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493730