Characterization of Kaposi's Sarcoma-Associated Herpesvirus-Related Lymphomas by DNA Microarray Analysis
Joint Authors
Zheng, Xin
Ueda, Keiji
Nakano, Kazushi
Ohsaki, Eriko
Source
Leukemia Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
Among herpesviruses, γ-herpesviruses are supposed to have typical oncogenic activities.
Two human γ-herpesviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), are putative etiologic agents for Burkitt lymphoma, nasopharyngeal carcinoma, and some cases of gastric cancers, and Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma (PEL) especially in AIDS setting for the latter case, respectively.
Since such two viruses mentioned above are highly species specific, it has been quite difficult to prove their oncogenic activities in animal models.
Nevertheless, the viral oncogenesis is epidemiologically and/or in vitro experimentally evident.
This time, we investigated gene expression profiles of KSHV-oriented lymphoma cell lines, EBV-oriented lymphoma cell lines, and T-cell leukemia cell lines.
Both KSHV and EBV cause a B-cell-originated lymphoma, but the gene expression profiles were typically classified.
Furthermore, KSHV could govern gene expression profiles, although PELs are usually coinfected with KSHV and EBV.
American Psychological Association (APA)
Ueda, Keiji& Ohsaki, Eriko& Nakano, Kazushi& Zheng, Xin. 2011. Characterization of Kaposi's Sarcoma-Associated Herpesvirus-Related Lymphomas by DNA Microarray Analysis. Leukemia Research and Treatment،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-493803
Modern Language Association (MLA)
Ueda, Keiji…[et al.]. Characterization of Kaposi's Sarcoma-Associated Herpesvirus-Related Lymphomas by DNA Microarray Analysis. Leukemia Research and Treatment No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-493803
American Medical Association (AMA)
Ueda, Keiji& Ohsaki, Eriko& Nakano, Kazushi& Zheng, Xin. Characterization of Kaposi's Sarcoma-Associated Herpesvirus-Related Lymphomas by DNA Microarray Analysis. Leukemia Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-493803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493803