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In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker
Joint Authors
Souza, Celeste da Silva Freitas
Almeida-Souza, Fernando
Colares, Aracélio Viana
Taniwaki, Noemi Nosomi
Abreu-Silva, Ana Lúcia
Calabrese, Kátia da Silva
Costa, José Galberto Martins da
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The search for new immunopharmacological chemical agents to treat various diseases caused by bacteria, fungi, and protozoa, such as leishmaniasis, for example, has led to the exploration of potential products from plant species and their main active ingredients.
Antimonial drugs are the current treatment for leishmaniasis.
These drugs cause major side effects and frequent discontinuation of treatment.
In this study, we evaluated the in vitro leishmanicidal activity of essential oil of Vanillosmopsis arborea (VAEO) and its major compound α-bisabolol against Leishmania amazonensis.
The essential oil and α-bisabolol showed activity against promastigotes (IC50 7.35 and 4.95 μg/mL resp.) and intracellular amastigotes (IC50 12.58 and 10.70 μg/mL, resp.).
Neither product showed any cytotoxicity on treated macrophages.
The ultrastructural analysis of promastigotes incubated with VAEO or α-bisabolol at 30 μg/mL, showed morphological changes with the accumulation of vesicles electrodense lipid inclusions.
The results give evidence that both VAEO and α-bisabolol have potential as new therapeutic agents against leishmaniasis.
American Psychological Association (APA)
Colares, Aracélio Viana& Almeida-Souza, Fernando& Taniwaki, Noemi Nosomi& Souza, Celeste da Silva Freitas& Costa, José Galberto Martins da& Calabrese, Kátia da Silva…[et al.]. 2013. In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-493811
Modern Language Association (MLA)
Colares, Aracélio Viana…[et al.]. In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-493811
American Medical Association (AMA)
Colares, Aracélio Viana& Almeida-Souza, Fernando& Taniwaki, Noemi Nosomi& Souza, Celeste da Silva Freitas& Costa, José Galberto Martins da& Calabrese, Kátia da Silva…[et al.]. In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-493811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493811