Chemokines and Neurodegeneration in the Early Stage of Experimental Ischemic Stroke
Joint Authors
Glabinski, Andrzej
Wolinski, Pawel
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Neurodegeneration is a hallmark of most of the central nervous system (CNS) disorders including stroke.
Recently inflammation has been implicated in pathogenesis of neurodegeneration and neurodegenerative diseases.
The aim of this study was analysis of expression of several inflammatory markers and its correlation with development of neurodegeneration during the early stage of experimental stroke.
Ischemic stroke model was induced by stereotaxic intracerebral injection of vasoconstricting agent endothelin-1 (ET-1).
It was observed that neurodegeneration appears very early in that model and correlates well with migration of inflammatory lymphocytes and macrophages to the brain.
Although the expression of several studied chemotactic cytokines (chemokines) was significantly increased at the early phase of ET-1 induced stroke model, no clear correlation of this expression with neurodegeneration was observed.
These data may indicate that chemokines do not induce neurodegeneration directly.
Upregulated in the ischemic brain chemokines may be a potential target for future therapies reducing inflammatory cell migration to the brain in early stroke.
Inhibition of inflammatory cell accumulation in the brain at the early stage of stroke may lead to amelioration of ischemic neurodegeneration.
American Psychological Association (APA)
Wolinski, Pawel& Glabinski, Andrzej. 2013. Chemokines and Neurodegeneration in the Early Stage of Experimental Ischemic Stroke. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-493826
Modern Language Association (MLA)
Wolinski, Pawel& Glabinski, Andrzej. Chemokines and Neurodegeneration in the Early Stage of Experimental Ischemic Stroke. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-493826
American Medical Association (AMA)
Wolinski, Pawel& Glabinski, Andrzej. Chemokines and Neurodegeneration in the Early Stage of Experimental Ischemic Stroke. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-493826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493826