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STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis
Joint Authors
Kimura, Takefumi
Katsuyama, Yoshihiko
Matsumoto, Akihiro
Yoshizawa, Kaname
Ishibashi, Hiromi
Ota, Masao
Shibata, Soichiro
Komatsu, Michiharu
Umemura, Takeji
Joshita, Satoru
Morita, Susumu
Tanaka, Eiji
Nakamura, Minoru
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Recent genome-wide association studies suggest that genetic factors contribute to primary biliary cirrhosis (PBC) susceptibility.
Although several reports have demonstrated that the interleukin (IL) 12 signaling pathway is involved in PBC pathogenesis, its precise genetic factors have not been fully clarified.
Here, we performed an association analysis between IL12A, IL12RB, and signal transducer and activator of transcription 4 (STAT4) genetic variations and susceptibility to PBC.
Single nucleotide polymorphisms (SNPs) were genotyped in 395 PBC patients and 458 healthy subjects of Japanese ethnicity and evaluated for associations with PBC susceptibility, anti-nuclear antibody (ANA) status, and anti-mitochondrial antibody (AMA) status.
We detected significant associations with PBC susceptibility for several STAT4 SNPs (rs10168266; P=9.4×10-3, rs11889341; P=1.2×10-3, rs7574865; P=4.0×10-4, rs8179673; P=2.0×10-4, and rs10181656; P=4.2×10-5).
Three risk alleles (rs7574865; P=0.040, rs8179673; P=0.032, and rs10181656; P=0.031) were associated with ANA status, but not with AMA positivity.
Our findings confirm that STAT4 is involved in PBC susceptibility and may play a role in ANA status in the Japanese population.
American Psychological Association (APA)
Joshita, Satoru& Umemura, Takeji& Nakamura, Minoru& Katsuyama, Yoshihiko& Shibata, Soichiro& Kimura, Takefumi…[et al.]. 2014. STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis. Disease Markers،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-493842
Modern Language Association (MLA)
Joshita, Satoru…[et al.]. STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis. Disease Markers No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-493842
American Medical Association (AMA)
Joshita, Satoru& Umemura, Takeji& Nakamura, Minoru& Katsuyama, Yoshihiko& Shibata, Soichiro& Kimura, Takefumi…[et al.]. STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-493842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493842