A New 3D Simulation Method for the Construction of Optical Phase Contrast Images of Gold Nanoparticle Clusters in Biological Cells
Joint Authors
Pond, James
Paddon, Paul
Tanev, Stoyan
Tuchin, Valery V.
Source
Advances in Optical Technologies
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-12-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Engineering Sciences and Information Technology
Abstract EN
A new 3D simulation method based on the finite-difference time domain (FDTD) approach in combination with Fourier optic techniques is applied to the modeling of optical phase contrast microscope (OPCM) imaging of gold nanoparticles (NPs) in singe biological cells.
We consider a realistic size 3D cell model at optical immersion conditions, that is, when the refractive index values of the cytoplasm and of the extracellular medium are equal.
For the first time, an FDTD-based OPCM model is applied to visualize the presence of a cluster of gold NPs in the cytoplasm at both resonant and nonresonant conditions.
The results demonstrate the capability to model OPCM image enhancement by optically controlling the resonant properties of the NPs.
Our research study extends the applicability of the FDTD modeling approach into a new biomedical optics research area.
American Psychological Association (APA)
Tanev, Stoyan& Pond, James& Paddon, Paul& Tuchin, Valery V.. 2008. A New 3D Simulation Method for the Construction of Optical Phase Contrast Images of Gold Nanoparticle Clusters in Biological Cells. Advances in Optical Technologies،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-493846
Modern Language Association (MLA)
Tanev, Stoyan…[et al.]. A New 3D Simulation Method for the Construction of Optical Phase Contrast Images of Gold Nanoparticle Clusters in Biological Cells. Advances in Optical Technologies No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-493846
American Medical Association (AMA)
Tanev, Stoyan& Pond, James& Paddon, Paul& Tuchin, Valery V.. A New 3D Simulation Method for the Construction of Optical Phase Contrast Images of Gold Nanoparticle Clusters in Biological Cells. Advances in Optical Technologies. 2008. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-493846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493846