Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release
Joint Authors
Yusuf, Mashitah M.
Lokman, Faradianna E.
Chia, Keh Leong
Gu, Harvest F.
Östenson, Claes-Göran
Wan Mohamud, Wan Nazaimoon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
To evaluate the antidiabetic properties of borapetol B known as compound 1 (C1) isolated from Tinospora crispa in normoglycemic control Wistar (W) and spontaneously type 2 diabetic Goto-Kakizaki (GK) rats.
Methods.
The effect of C1 on blood glucose and plasma insulin was assessed by an oral glucose tolerance test.
The effect of C1 on insulin secretion was assessed by batch incubation and perifusion experiments using isolated pancreatic islets.
Results.
An acute oral administration of C1 improved blood glucose levels in treated versus placebo groups with areas under glucose curves 0–120 min being 72±17 versus 344±10 mmol/L (P<0.001) and 492±63 versus 862±55 mmol/L (P<0.01) in W and GK rats, respectively.
Plasma insulin levels were increased by 2-fold in treated W and GK rats versus placebo group at 30 min (P<0.05).
C1 dose-dependently increased insulin secretion from W and GK isolated islets at 3.3 mM and 16.7 mM glucose.
The perifusions of isolated islets indicated that C1 did not cause leakage of insulin by damaging islet beta cells (P<0.001).
Conclusion.
This study provides evidence that borapetol B (C1) has antidiabetic properties mainly due to its stimulation of insulin release.
American Psychological Association (APA)
Lokman, Faradianna E.& Gu, Harvest F.& Wan Mohamud, Wan Nazaimoon& Yusuf, Mashitah M.& Chia, Keh Leong& Östenson, Claes-Göran. 2013. Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-493856
Modern Language Association (MLA)
Lokman, Faradianna E.…[et al.]. Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-493856
American Medical Association (AMA)
Lokman, Faradianna E.& Gu, Harvest F.& Wan Mohamud, Wan Nazaimoon& Yusuf, Mashitah M.& Chia, Keh Leong& Östenson, Claes-Göran. Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-493856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493856