The Calcium-Dependent Interaction of S100B with Its Protein Targets
Joint Authors
Weber, David J.
Zimmer, Danna B.
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-17
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
S100B is a calcium signaling protein that is a member of the S100 protein family.
An important feature of S100B and most other S100 proteins (S100s) is that they often bind Ca2+ ions relatively weakly in the absence of a protein target; upon binding their target proteins, Ca2+-binding then increases by as much as from 200- to 400-fold.
This manuscript reviews the structural basis and physiological significance of increased Ca2+-binding affinity in the presence of protein targets.
New information regarding redundancy among family members and the structural domains that mediate the interaction of S100B, and other S100s, with their targets is also presented.
It is the diversity among individual S100s, the protein targets that they interact with, and the Ca2+ dependency of these protein-protein interactions that allow S100s to transduce changes in [Ca2+]intracellular levels into spatially and temporally unique biological responses.
American Psychological Association (APA)
Zimmer, Danna B.& Weber, David J.. 2010. The Calcium-Dependent Interaction of S100B with Its Protein Targets. Cardiovascular Psychiatry and Neurology،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-493884
Modern Language Association (MLA)
Zimmer, Danna B.& Weber, David J.. The Calcium-Dependent Interaction of S100B with Its Protein Targets. Cardiovascular Psychiatry and Neurology No. 2010 (2010), pp.1-17.
https://search.emarefa.net/detail/BIM-493884
American Medical Association (AMA)
Zimmer, Danna B.& Weber, David J.. The Calcium-Dependent Interaction of S100B with Its Protein Targets. Cardiovascular Psychiatry and Neurology. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-493884
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493884