Systemic Mastocytosis : A Rare Case of Increased Liver Stiffness
Joint Authors
Adolf, Stefanie
Seitz, Helmut Karl
Longerich, Thomas
Millonig, Gunda
Schirmacher, Peter
Reiter, Andreas
Mueller, Sebastian
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Assessment of liver stiffness (LS) by transient elastography (Fibroscan) has significantly improved the noninvasive diagnosis of liver fibrosis.
We here report on a 55-year-old patient with drastically increased LS due to previously unknown systemic mastocytosis.
The patient initially presented with increased weight loss, nocturnal pruritus, increased transaminases, bilirubinemia, and thrombocytopenia.
Abdominal ultrasound showed ascites, hepatomegaly, and splenomegaly.
In addition, LS was 75 kPa (IQR 0 kPa) clearly exceeding the cut-off value for F4 cirrhosis of 12.5 kPa.
However, histological analysis of the liver specimen indicated liver involvement by systemic mastocytosis and excluded liver cirrhosis.
An additional CT scan detected disseminated bone lesions.
After three months of treatment with Midostaurin, LS slightly decreased down to 31.9 kPa (IQR 8.3 kPa).
This case illustrates that diffused sinusoidal neoplastic infiltrates are a pitfall in the non-invasive diagnosis of liver cirrhosis.
In conclusion, refined clinical algorithms for increased LS should also include mastocytosis in addition to inflammation, congestion, and biliary obstruction.
American Psychological Association (APA)
Adolf, Stefanie& Millonig, Gunda& Seitz, Helmut Karl& Reiter, Andreas& Schirmacher, Peter& Longerich, Thomas…[et al.]. 2012. Systemic Mastocytosis : A Rare Case of Increased Liver Stiffness. Case Reports in Hepatology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-493895
Modern Language Association (MLA)
Adolf, Stefanie…[et al.]. Systemic Mastocytosis : A Rare Case of Increased Liver Stiffness. Case Reports in Hepatology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-493895
American Medical Association (AMA)
Adolf, Stefanie& Millonig, Gunda& Seitz, Helmut Karl& Reiter, Andreas& Schirmacher, Peter& Longerich, Thomas…[et al.]. Systemic Mastocytosis : A Rare Case of Increased Liver Stiffness. Case Reports in Hepatology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-493895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493895