The Role of Angiogenesis in the Development of Proliferative Diabetic Retinopathy : Impact of Intravitreal Anti-VEGF Treatment
Joint Authors
Zerbini, Gianpaolo
Tremolada, Gemma
Lattanzio, Rosangela
Bandello, Francesco
Maestroni, Anna
Del Turco, Claudia
Maestroni, Silvia
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Although cellular and molecular bases of proliferative diabetic retinopathy are only partially understood, it is evident that this complication of diabetes is characterized by the formation of new vessels inside the retina showing abnormal architecture and permeability.
This process, if not controlled by selective laser photocoagulation, leads to irreversible retinal damages and loss of vision.
Angiogenesis, that is, the condition characterized by the growth of new blood vessels originated from preexisting ones, was shown to have a major role in the pathogenesis of proliferative retinopathy and, as a consequence, intravitreal antiangiogenic injection was suggested as a feasible treatment for this disease.
Here, we describe the different antiangiogenic approaches used to treat this disease along with the respective advantages and limitations when compared to laser treatment.
Altogether, even though further and longer studies are still needed to clarify the best possible therapeutic protocol, the antiangiogenic treatment will reasonably have a future role in the therapy and prevention of proliferative diabetic retinopathy.
American Psychological Association (APA)
Tremolada, Gemma& Del Turco, Claudia& Lattanzio, Rosangela& Maestroni, Silvia& Maestroni, Anna& Bandello, Francesco…[et al.]. 2012. The Role of Angiogenesis in the Development of Proliferative Diabetic Retinopathy : Impact of Intravitreal Anti-VEGF Treatment. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-493909
Modern Language Association (MLA)
Tremolada, Gemma…[et al.]. The Role of Angiogenesis in the Development of Proliferative Diabetic Retinopathy : Impact of Intravitreal Anti-VEGF Treatment. Experimental Diabetes Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-493909
American Medical Association (AMA)
Tremolada, Gemma& Del Turco, Claudia& Lattanzio, Rosangela& Maestroni, Silvia& Maestroni, Anna& Bandello, Francesco…[et al.]. The Role of Angiogenesis in the Development of Proliferative Diabetic Retinopathy : Impact of Intravitreal Anti-VEGF Treatment. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-493909
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493909