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Preparation and Characterization of Self-Microemulsifying Drug Delivery System of Olmesartan Medoxomil for Bioavailability Improvement
Joint Authors
Prajapati, Shailesh T.
Patel, Chhaganbhai N.
Joshi, Harsh A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology
Abstract EN
Olmesartan medoxomil (OLM) is an angiotensin II receptor blocker (ARB) antihypertensive agent administered orally that has absolute bioavailability of only 26% due to the poor aqueous solubility (7.75 μg/ml).
The aim of the present investigation was to develop a self-microemulsifying drug delivery system (SMEDDS) to enhance the oral absorption of OLM.
The solubility of OLM in various oils, surfactants, and cosurfactants was determined.
Pseudoternary phase diagrams were constructed using Acrysol EL 135, Tween 80, Transcutol P, and distilled water to identify the efficient self-microemulsification region.
Prepared SMEDDS was further evaluated for its emulsification time, drug content, optical clarity, droplet size, zeta potential, in vitro dissolution, and in vitro and ex vivo drug diffusion study.
The optimized formulation S2 contained OLM (20 mg), Tween 80 (33%v/v), Transcutol P (33%v/v), and Acrysol EL 135 (34%v/v) had shown the smallest particle size, maximum solubility, less emulsification time, good optical clarity, and in vitro release.
The in vitro and ex vivo diffusion rate of the drug from the SMEDDS was significantly higher than that of the plain drug suspension.
It was concluded that SMEDDS would be a promising drug delivery system for poorly water-soluble drugs by the oral route.
American Psychological Association (APA)
Prajapati, Shailesh T.& Joshi, Harsh A.& Patel, Chhaganbhai N.. 2012. Preparation and Characterization of Self-Microemulsifying Drug Delivery System of Olmesartan Medoxomil for Bioavailability Improvement. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-493921
Modern Language Association (MLA)
Prajapati, Shailesh T.…[et al.]. Preparation and Characterization of Self-Microemulsifying Drug Delivery System of Olmesartan Medoxomil for Bioavailability Improvement. Journal of Pharmaceutics No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-493921
American Medical Association (AMA)
Prajapati, Shailesh T.& Joshi, Harsh A.& Patel, Chhaganbhai N.. Preparation and Characterization of Self-Microemulsifying Drug Delivery System of Olmesartan Medoxomil for Bioavailability Improvement. Journal of Pharmaceutics. 2012. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-493921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493921