DNA Mismatch Repair System : Repercussions in Cellular Homeostasis and Relationship with Aging
Joint Authors
Conde-Pérezprina, Juan Cristóbal
Konigsberg, Mina
León-Galván, Miguel Ángel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The mechanisms that concern DNA repair have been studied in the last years due to their consequences in cellular homeostasis.
The diverse and damaging stimuli that affect DNA integrity, such as changes in the genetic sequence and modifications in gene expression, can disrupt the steady state of the cell and have serious repercussions to pathways that regulate apoptosis, senescence, and cancer.
These altered pathways not only modify cellular and organism longevity, but quality of life (“health-span”).
The DNA mismatch repair system (MMR) is highly conserved between species; its role is paramount in the preservation of DNA integrity, placing it as a necessary focal point in the study of pathways that prolong lifespan, aging, and disease.
Here, we review different insights concerning the malfunction or absence of the DNA-MMR and its impact on cellular homeostasis.
In particular, we will focus on DNA-MMR mechanisms regulated by known repair proteins MSH2, MSH6, PMS2, and MHL1, among others.
American Psychological Association (APA)
Conde-Pérezprina, Juan Cristóbal& León-Galván, Miguel Ángel& Konigsberg, Mina. 2012. DNA Mismatch Repair System : Repercussions in Cellular Homeostasis and Relationship with Aging. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-493922
Modern Language Association (MLA)
Conde-Pérezprina, Juan Cristóbal…[et al.]. DNA Mismatch Repair System : Repercussions in Cellular Homeostasis and Relationship with Aging. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-493922
American Medical Association (AMA)
Conde-Pérezprina, Juan Cristóbal& León-Galván, Miguel Ángel& Konigsberg, Mina. DNA Mismatch Repair System : Repercussions in Cellular Homeostasis and Relationship with Aging. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-493922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493922