Interocular Asymmetry of Foveal Thickness in Parkinson Disease
Joint Authors
Bodis-Wollner, Ivan
Glazman, Sofya
Spund, Brian
Shrier, Eric M.
Adam, Christopher R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
To quantify interocular asymmetry (IA) of foveal thickness in Parkinson disease (PD) versus that of controls.
Design.
Prospective case-control series.
Methods.
In vivo assessment of foveal thickness of 46 eyes of 23 PD patients and 36 eyes of 18 control subjects was studied using spectral domain optical coherence tomography (SD-OCT).
Inner versus outer layer retinal segmentation and macular volumes were quantified using the manufacturer's software, while foveal thickness was measured using the raw data from each eye in a grid covering a 6 by 6 mm area centered on the foveola in 0.25 mm steps.
Thickness data were entered into MATLAB software.
Results.
Macular volumes differed significantly at the largest (Zone 3) diameter centered on the foveola (ETDRS protocol).
By segmenting inner from outer layers, we found that the IA in PD is mostly due to changes on the slope of the foveal pit at the radial distances of 0.5 and 0.75 mm (1.5 mm and 1 mm diameter).
Conclusions.
About half of the PD patients had IA of the slope of the foveal pit.
IA is a potentially useful marker of PD and is expected to be comparable across different SD-OCT equipment.
Data of larger groups may be developed in future multicenter studies.
American Psychological Association (APA)
Shrier, Eric M.& Adam, Christopher R.& Spund, Brian& Glazman, Sofya& Bodis-Wollner, Ivan. 2012. Interocular Asymmetry of Foveal Thickness in Parkinson Disease. Journal of Ophthalmology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-493925
Modern Language Association (MLA)
Shrier, Eric M.…[et al.]. Interocular Asymmetry of Foveal Thickness in Parkinson Disease. Journal of Ophthalmology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-493925
American Medical Association (AMA)
Shrier, Eric M.& Adam, Christopher R.& Spund, Brian& Glazman, Sofya& Bodis-Wollner, Ivan. Interocular Asymmetry of Foveal Thickness in Parkinson Disease. Journal of Ophthalmology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-493925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493925