p38 MAPK Signaling in Pemphigus : Implications for Skin Autoimmunity
Joint Authors
Sakkas, Lazaros I.
Bogdanos, Dimitrios P.
Liaskos, Christos
Mavropoulos, Athanasios
Spyrou, Vassiliki
Smyk, Daniel S.
Orfanidou, Timoklia
Rigopoulou, Eirini I.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
p38 mitogen activated protein kinase (p38 MAPK) signaling plays a major role in the modulation of immune-mediated inflammatory responses and therefore has been linked with several autoimmune diseases.
The extent of the involvement of p38 MAPK in the pathogenesis of autoimmune blistering diseases has started to emerge, but whether it pays a critical role is a matter of debate.
The activity of p38 MAPK has been studied in great detail during the loss of keratinocyte cell-cell adhesions and the development of pemphigus vulgaris (PV) and pemphigus foliaceus (PF).
These diseases are characterised by autoantibodies targeting desmogleins (Dsg).
Whether autoantibody-antigen interactions can trigger signaling pathways (such as p38 MAPK) that are tightly linked to the secretion of inflammatory mediators which may perpetuate inflammation and tissue damage in pemphigus remains unclear.
Yet, the ability of p38 MAPK inhibitors to block activation of the proapoptotic proteinase caspase-3 suggests that the induction of apoptosis may be a consequence of p38 MAPK activation during acantholysis in PV.
This review discusses the current evidence for the role of p38 MAPK in the pathogenesis of pemphigus.
We will also present data relating to the targeting of these cascades as a means of therapeutic intervention.
American Psychological Association (APA)
Mavropoulos, Athanasios& Orfanidou, Timoklia& Liaskos, Christos& Smyk, Daniel S.& Spyrou, Vassiliki& Sakkas, Lazaros I.…[et al.]. 2013. p38 MAPK Signaling in Pemphigus : Implications for Skin Autoimmunity. Autoimmune Diseases،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-493937
Modern Language Association (MLA)
Mavropoulos, Athanasios…[et al.]. p38 MAPK Signaling in Pemphigus : Implications for Skin Autoimmunity. Autoimmune Diseases No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-493937
American Medical Association (AMA)
Mavropoulos, Athanasios& Orfanidou, Timoklia& Liaskos, Christos& Smyk, Daniel S.& Spyrou, Vassiliki& Sakkas, Lazaros I.…[et al.]. p38 MAPK Signaling in Pemphigus : Implications for Skin Autoimmunity. Autoimmune Diseases. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-493937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493937