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Is Physical Activity Able to Modify Oxidative Damage in Cardiovascular Aging?
Joint Authors
Ciccarelli, Anna Linda
Rengo, Giuseppe
Filippelli, Amelia
Conti, Valeria
Ferrara, Nicola
Corbi, Graziamaria
Russomanno, Giusy
Vitulli, Piergiusto
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Aging is a multifactorial process resulting in damage of molecules, cells, and tissues.
It has been demonstrated that the expression and activity of antioxidant systems (SOD, HSPs) are modified in aging, with reduced cell ability to counteract the oxidant molecules, and consequent weak resistance to ROS accumulation.
An important mechanism involved is represented by sirtuins, the activity of which is reduced by aging.
Physical activity increases the expression and the activity of antioxidant enzymes, with consequent reduction of ROS.
Positive effects of physical exercise in terms of antioxidant activity could be ascribable to a greater expression and activity of SOD enzymes, HSPs and SIRT1 activity.
The antioxidant effects could increase, decrease, or not change in relation to the exercise protocol.
Therefore, some authors by using a new approach based on the in vivo/vitro technique demonstrated that the highest survival and proliferation and the lowest senescence were obtained by performing an aerobic training.
Therefore, the in vivo/vitro technique described could represent a good tool to better understand how the exercise training mediates its effects on aging-related diseases, as elderly with heart failure that represents a special population in which the exercise plays an important role in the improvement of cardiovascular function, quality of life, and survival.
American Psychological Association (APA)
Corbi, Graziamaria& Conti, Valeria& Russomanno, Giusy& Rengo, Giuseppe& Vitulli, Piergiusto& Ciccarelli, Anna Linda…[et al.]. 2012. Is Physical Activity Able to Modify Oxidative Damage in Cardiovascular Aging?. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-493941
Modern Language Association (MLA)
Corbi, Graziamaria…[et al.]. Is Physical Activity Able to Modify Oxidative Damage in Cardiovascular Aging?. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-493941
American Medical Association (AMA)
Corbi, Graziamaria& Conti, Valeria& Russomanno, Giusy& Rengo, Giuseppe& Vitulli, Piergiusto& Ciccarelli, Anna Linda…[et al.]. Is Physical Activity Able to Modify Oxidative Damage in Cardiovascular Aging?. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-493941
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493941