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Effect of Novel Marine Nutraceuticals on IL-1α-Mediated TNF-α Release from UVB-Irradiated Human Melanocyte-Derived Cells
Joint Authors
Piva, Terrence J.
Muthusamy, Visalini
Hodges, Lynn D.
Boyle, Glen M.
Macrides, Theodore A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
UV-induced inflammation and reactive oxygen species formation are involved in the development of melanoma.
Natural products like 5β-scymnol and CO2-supercritical fluid extract (CO2-SFE) of mussel oil contain anti-inflammatory and antioxidant properties that may aid in reducing the deleterious effects of UV radiation.
Therefore, their effect on the release of the proinflammatory cytokine, tumour necrosis factor-α (TNF-α), from UVB-irradiated human melanocytic cells was examined.
Human epidermal melanocytes (HEM) and MM96L melanoma cells were exposed to UVB radiation and IL-1α.
Cell viability and TNF-α levels were determined 24 hours after-irradiation while p38 mitogen-activated protein kinase (MAPK) activation was observed at 15 min after-irradiation.
When α-tocopherol, CO2-SFE mussel oil, and 5β-scymnol were added to the UVB-irradiated HEM cells treated with IL-1α, TNF-α levels fell by 53%, 65%, and 76%, respectively, while no inhibition was evident in MM96L cells.
This effect was not due to inhibition of the intracellular p38 MAPK signalling pathway.
These compounds may be useful in preventing inflammation-induced damage to normal melanocytes.
American Psychological Association (APA)
Muthusamy, Visalini& Hodges, Lynn D.& Macrides, Theodore A.& Boyle, Glen M.& Piva, Terrence J.. 2011. Effect of Novel Marine Nutraceuticals on IL-1α-Mediated TNF-α Release from UVB-Irradiated Human Melanocyte-Derived Cells. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-493956
Modern Language Association (MLA)
Muthusamy, Visalini…[et al.]. Effect of Novel Marine Nutraceuticals on IL-1α-Mediated TNF-α Release from UVB-Irradiated Human Melanocyte-Derived Cells. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-493956
American Medical Association (AMA)
Muthusamy, Visalini& Hodges, Lynn D.& Macrides, Theodore A.& Boyle, Glen M.& Piva, Terrence J.. Effect of Novel Marine Nutraceuticals on IL-1α-Mediated TNF-α Release from UVB-Irradiated Human Melanocyte-Derived Cells. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-493956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493956