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Antibodies to Glycoproteins Shared by Human Peripheral Nerve and Campylobacter jejuni in Patients with Multifocal Motor Neuropathy
Joint Authors
Suturkova, Ljubica
Grozdanova, Aleksandra
Brezovska, Katerina
Knežević Apostolski, Sladjana
Poceva-Panovska, Ana
Basta, Ivana
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We have tested serum samples from 24 patients with multifocal motor neuropathy (MMN) for reactivity to ganglioside GM1 and to Gal(β1–3)GalNAc-bearing glycoproteins isolated from human peripheral nerve and from Campylobacter jejuni (Cj) serotype O:19.
IgM anti-GM1 antibodies were detected by ELISA in 11 patients (45.8%) with MMN and in only one subject (4%) from the control group.
Western blots showed positive reactivity of sera from 6 patients (25%) with MMN to several Gal(β1–3)GalNAc-bearing glycoproteins from human peripheral nerve and from Cj O:19 isolates.
Sera from three patients (12.5%) with MMN showed positively reactive bands with similar electrophoretic mobility in all isolates (60–62 kDa, 48–51 kDa, 42 kDa, and 38 kDa).
All six patients showed positive reactivity to 48–52 kDa protein isolated from human peripheral nerve.
Increased titer of IgG antibodies to 60–62 kDa protein isolated from Cj O:19 associated with Guillain-Barré syndrome was detected in three patients, and their serum showed also IgG positive reactivity to peripheral nerve antigen with the same electrophoretic mobility.
One of these patients had a previous history of Cj infection which suggests the possibility that Cj may be also involved in the pathogenesis of MMN.
American Psychological Association (APA)
Suturkova, Ljubica& Brezovska, Katerina& Poceva-Panovska, Ana& Grozdanova, Aleksandra& Knežević Apostolski, Sladjana& Basta, Ivana. 2013. Antibodies to Glycoproteins Shared by Human Peripheral Nerve and Campylobacter jejuni in Patients with Multifocal Motor Neuropathy. Autoimmune Diseases،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-493957
Modern Language Association (MLA)
Suturkova, Ljubica…[et al.]. Antibodies to Glycoproteins Shared by Human Peripheral Nerve and Campylobacter jejuni in Patients with Multifocal Motor Neuropathy. Autoimmune Diseases No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-493957
American Medical Association (AMA)
Suturkova, Ljubica& Brezovska, Katerina& Poceva-Panovska, Ana& Grozdanova, Aleksandra& Knežević Apostolski, Sladjana& Basta, Ivana. Antibodies to Glycoproteins Shared by Human Peripheral Nerve and Campylobacter jejuni in Patients with Multifocal Motor Neuropathy. Autoimmune Diseases. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-493957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493957