New Acetylcholinesterase Inhibitors for Alzheimer's Disease
Joint Authors
Sabbagh, Marwan N.
Adem, Abdu
Mehta, Mona
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Acetylcholinesterase (AChE) remains a highly viable target for the symptomatic improvement in Alzheimer's disease (AD) because cholinergic deficit is a consistent and early finding in AD.
The treatment approach of inhibiting peripheral AchE for myasthenia gravis had effectively proven that AchE inhibition was a reachable therapeutic target.
Subsequently tacrine, donepezil, rivastigmine, and galantamine were developed and approved for the symptomatic treatment of AD.
Since then, multiple cholinesterase inhibitors (ChEI) continue to be developed.
These include newer ChEIs, naturally derived ChEIs, hybrids, and synthetic analogues.
In this paper, we summarize the different types of ChEIs in development and their respective mechanisms of actions.
This pharmacological approach continues to be active with many promising compounds.
American Psychological Association (APA)
Mehta, Mona& Adem, Abdu& Sabbagh, Marwan N.. 2011. New Acetylcholinesterase Inhibitors for Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-493976
Modern Language Association (MLA)
Mehta, Mona…[et al.]. New Acetylcholinesterase Inhibitors for Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-493976
American Medical Association (AMA)
Mehta, Mona& Adem, Abdu& Sabbagh, Marwan N.. New Acetylcholinesterase Inhibitors for Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-493976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493976