Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads
Joint Authors
Kodama, Youko
Murata, Yoshifumi
Isobe, Takashi
Kawashima, Susumu
Kofuji, Kyoko
Source
International Journal of Polymer Science
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-01-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Calcium-induced alginate-phosphate composite gel beads were prepared, and model drug release profiles were investigated in vitro.
The formation of calcium phosphate in the alginate gel matrix was observed and did not affect the rheological properties of the hydrogel beads.
X-ray diffraction patterns showed that the calcium phosphate does not exist in crystalline form in the matrix.
The initial release amount and release rate of a water-soluble drug, diclofenac, from the alginate gel beads could be controlled by modifying the composition of the matrix with calcium phosphate.
In contrast, the release profile was not affected by the modification for hydrocortisone, a drug only slightly soluble in water.
American Psychological Association (APA)
Murata, Yoshifumi& Kodama, Youko& Isobe, Takashi& Kofuji, Kyoko& Kawashima, Susumu. 2009. Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads. International Journal of Polymer Science،Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-493983
Modern Language Association (MLA)
Murata, Yoshifumi…[et al.]. Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads. International Journal of Polymer Science No. 2009 (2009), pp.1-4.
https://search.emarefa.net/detail/BIM-493983
American Medical Association (AMA)
Murata, Yoshifumi& Kodama, Youko& Isobe, Takashi& Kofuji, Kyoko& Kawashima, Susumu. Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads. International Journal of Polymer Science. 2009. Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-493983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493983