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TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains
Joint Authors
Ansaloni, Sara
Saunders, Aleister J.
Gadaleta, Mariana
Leung, Brian P.
Sebastian, Neeraj P.
Samudralwar, Rohini
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We report that NTRK2, the gene encoding for the TrkB receptor, can regulate APP metabolism, specifically AICD levels.
Using the human neuroblastoma cell line SH-SY5Y, we characterized the effect of three TrkB isoforms (FL, SHC, T) on APP metabolism by knockdown and overexpression.
We found that TrkB FL increases AICD-mediated transcription and APP levels while it decreases sAPP levels.
These effects were mainly mediated by the tyrosine kinase activity of the receptor and partially by the PLC-γ- and SHC-binding sites.
The TrkB T truncated isoform did not have significant effects on APP metabolism when transfected by itself, while the TrkB SHC decreased AICD-mediated transcription.
TrkB T abolished TrkB FL effects on APP metabolism when cotransfected with it while TrkB SHC cotransfected with TrkB FL still showed increased APP levels.
In conclusion, we demonstrated that TrkB isoforms have differential effects on APP metabolism.
American Psychological Association (APA)
Ansaloni, Sara& Leung, Brian P.& Sebastian, Neeraj P.& Samudralwar, Rohini& Gadaleta, Mariana& Saunders, Aleister J.. 2011. TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-494018
Modern Language Association (MLA)
Ansaloni, Sara…[et al.]. TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-494018
American Medical Association (AMA)
Ansaloni, Sara& Leung, Brian P.& Sebastian, Neeraj P.& Samudralwar, Rohini& Gadaleta, Mariana& Saunders, Aleister J.. TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-494018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494018