Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment : An ADNI Study
Joint Authors
The Alzheimer's Disease Neuroimaging Initiative (ADNI),
Weiner, Michael W.
Swaminathan, Shanker
Saykin, Andrew J.
Huentelman, Matthew J.
Shen, Li
Pankratz, Nathan
Craig, David W.
Risacher, Shannon L.
Potkin, Steven G.
Kim, Sungeun
Foroud, Tatiana
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Copy number variants (CNVs) are DNA sequence alterations, resulting in gains (duplications) and losses (deletions) of genomic segments.
They often overlap genes and may play important roles in disease.
Only one published study has examined CNVs in late-onset Alzheimer's disease (AD), and none have examined mild cognitive impairment (MCI).
CNV calls were generated in 288 AD, 183 MCI, and 184 healthy control (HC) non-Hispanic Caucasian Alzheimer's Disease Neuroimaging Initiative participants.
After quality control, 222 AD, 136 MCI, and 143 HC participants were entered into case/control association analyses, including candidate gene and whole genome approaches.
Although no excess CNV burden was observed in cases (AD and/or MCI) relative to controls (HC), gene-based analyses revealed CNVs overlapping the candidate gene CHRFAM7A, as well as CSMD1, SLC35F2, HNRNPCL1, NRXN1, and ERBB4 regions, only in cases.
Replication in larger samples is important, after which regions detected here may be promising targets for resequencing.
American Psychological Association (APA)
Swaminathan, Shanker& Kim, Sungeun& Shen, Li& Risacher, Shannon L.& Foroud, Tatiana& Pankratz, Nathan…[et al.]. 2011. Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment : An ADNI Study. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-494029
Modern Language Association (MLA)
Swaminathan, Shanker…[et al.]. Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment : An ADNI Study. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-494029
American Medical Association (AMA)
Swaminathan, Shanker& Kim, Sungeun& Shen, Li& Risacher, Shannon L.& Foroud, Tatiana& Pankratz, Nathan…[et al.]. Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment : An ADNI Study. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-494029
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494029