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Image Processing Techniques for Assessing Contractility in Isolated Neonatal Cardiac Myocytes
Joint Authors
Torres Barba, David
Bazan, Carlos
Paolini, Paul
Blomgren, Peter
Source
International Journal of Biomedical Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We describe a computational framework for the quantitative assessment of contractile responses of isolated neonatal cardiac myocytes.
To the best of our knowledge, this is the first report on a practical and accessible method for the assessment of contractility in neonatal cardiocytes.
The proposed methodology is comprised of digital video recording of the contracting cell, signal preparation, representation by polar Fourier descriptors, and contractility assessment.
The different processing stages are variants of mathematically sound and computationally robust algorithms very well established in the scientific community.
The described computational approach provides a comprehensive assessment of the neonatal cardiac myocyte contraction without the need of elaborate instrumentation.
The versatility of the methodology allows it to be employed in determining myocyte contractility almost simultaneously with the acquisition of the Ca2+ transient and other correlates of cell contraction.
The proposed methodology can be utilized to evaluate changes in contractile behavior resulting from drug intervention, disease models, transgeneity, or other common applications of neonatal cardiocytes.
American Psychological Association (APA)
Bazan, Carlos& Torres Barba, David& Blomgren, Peter& Paolini, Paul. 2011. Image Processing Techniques for Assessing Contractility in Isolated Neonatal Cardiac Myocytes. International Journal of Biomedical Imaging،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-494051
Modern Language Association (MLA)
Blomgren, Peter…[et al.]. Image Processing Techniques for Assessing Contractility in Isolated Neonatal Cardiac Myocytes. International Journal of Biomedical Imaging No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-494051
American Medical Association (AMA)
Bazan, Carlos& Torres Barba, David& Blomgren, Peter& Paolini, Paul. Image Processing Techniques for Assessing Contractility in Isolated Neonatal Cardiac Myocytes. International Journal of Biomedical Imaging. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-494051
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494051