Role of HER2-Targeted Agents in Adjuvant Treatment for Breast Cancer

Author

Mukohara, Toru

Source

Chemotherapy Research and Practice

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-09-25

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Pharmacology

Abstract EN

Approximately 20% of breast cancers overexpress human epidermal growth factor receptor 2 (HER2) protein, mainly as a result of gene amplification.

The receptor tyrosine kinase is believed to play a critical role in the pathogenesis and further proliferation of these tumors.

The application of trastuzumab, a humanized monoclonal antibody against the extracellular domain of HER2 protein, to HER2-positive metastatic breast cancer has significantly improved treatment outcomes.

Following this success, several phase III trials have evaluated the role of trastuzumab in the adjuvant setting, with the result that trastuzumab use is now the standard of care for most HER2-positive early breast cancer patients.

In this paper, we review these pivotal phase III trials.

We also discuss unresolved issues in adjuvant treatment with trastuzumab, including target patient population, sequential or concurrent use with chemotherapy or radiation, treatment duration, cardiotoxicity, and the possibility of eliminating chemotherapy.

Following confirmation of its ability to partially overcome trastuzumab resistance, we also discuss the role of lapatinib in adjuvant use.

American Psychological Association (APA)

Mukohara, Toru. 2011. Role of HER2-Targeted Agents in Adjuvant Treatment for Breast Cancer. Chemotherapy Research and Practice،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-494092

Modern Language Association (MLA)

Mukohara, Toru. Role of HER2-Targeted Agents in Adjuvant Treatment for Breast Cancer. Chemotherapy Research and Practice No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-494092

American Medical Association (AMA)

Mukohara, Toru. Role of HER2-Targeted Agents in Adjuvant Treatment for Breast Cancer. Chemotherapy Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-494092

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-494092