Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia
Joint Authors
Shao, Zonghong
Ding, Kai
Liu, Hui
Wang, Huaquan
Li, Lijuan
Wang, Honglei
Yu, Hong
Wang, Yihao
Zhang, Jiangbo
Fu, Rong
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Immune-related pancytopenia (IRP) is one kind of bone marrow failure diseases which is related to autoantibodies.
Autoantibodies have been detected on the membrane of various bone marrow (BM) hemopoietic cells by BM mononuclear-cell-Coombs test or flow cytometric analysis.
There are autoantibodies in the BM supernatant of IRP patients, which can target several antigens on hematopoietic cells membranes by western blot.
T follicular helper (Tfh) cells are the true helper cells for Ab responses, which represent one of the most numerous and important subsets of effector T cells.
Dysregulation of Tfh cell function or expression of Tfh cell-associated molecules could contribute to the pathogenesis of autoimmune diseases.
Currently, there are no studies regarding the role of Tfh cells in IRP patients.
The percentages of Tfh cells, Tfh-related molecules ICOS, CD40L, IL-21, and Bcl-6 in BM were investigated in 90 patients with IRP, and 25 healthy controls.
We observed that there exist increased quantity and hyperfunction of Tfh cells in IRP, and the results were correlated with patient characteristics.
It was indicated that dysregulated Tfh cells might be involved in the pathogenesis of IRP and that inhibition of Tfh cells effector molecules might provide opportunities for new therapeutic approaches to IRP and even other human autoimmune diseases.
American Psychological Association (APA)
Yu, Hong& Zhang, Jiangbo& Fu, Rong& Liu, Hui& Wang, Huaquan& Ding, Kai…[et al.]. 2013. Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-494100
Modern Language Association (MLA)
Yu, Hong…[et al.]. Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia. Clinical and Developmental Immunology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-494100
American Medical Association (AMA)
Yu, Hong& Zhang, Jiangbo& Fu, Rong& Liu, Hui& Wang, Huaquan& Ding, Kai…[et al.]. Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-494100
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494100