Genistein Attenuates Vascular Endothelial Impairment in Ovariectomized Hyperhomocysteinemic Rats
Joint Authors
Zhao, Qian
Liu, Teng
Jiang, Dongqiao
Wang, Wen
Lu, Lingqiao
Zhen, Panpan
Duan, Jinhong
Hou, Dandan
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hyperhomocysteinemia (HHcy) is a well-known independent risk factor for vascular diseases in the general population.
This study was to explore the effect of genistein (GST), a natural bioactive compound derived from legumes, on HHcy-induced vascular endothelial impairment in ovariectomized rats in vivo.
Thirty-two adult female Wistar rats were assigned randomly into four groups (n=8): (a) Con: control; (b) Met: 2.5% methionine diet; (c) OVX + Met: ovariectomy + 2.5% methionine diet; (d) OVX + Met + GST: ovariectomy + 2.5% methionine diet + supplementation with genistein.
After 12 wk of different treatment, the rats' blood, toracic aortas and liver samples were collected for analysis.
Results showed that high-methionine diet induced both elevation of plasma Hcy and endothelial dysfunction, and ovariectomy deteriorated these injuries.
Significant improvement of both functional and morphological changes of vascular endothelium was observed in OVX + Met + GST group; meanwhile the plasma Hcy levels decreased remarkably.
There were significant elevations of plasma ET-1 and liver MDA levels in ovariectomized HHcy rats, and supplementation with genistein could attenuate these changes.
These results implied that genistein could lower the elevated Hcy levels, and prevent the development of endothelial impairment in ovariectomized HHcy rats.
This finding may shed a novel light on the anti-atherogenic activities of genistein in HHcy patients.
American Psychological Association (APA)
Zhen, Panpan& Zhao, Qian& Hou, Dandan& Liu, Teng& Jiang, Dongqiao& Duan, Jinhong…[et al.]. 2012. Genistein Attenuates Vascular Endothelial Impairment in Ovariectomized Hyperhomocysteinemic Rats. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-494103
Modern Language Association (MLA)
Zhen, Panpan…[et al.]. Genistein Attenuates Vascular Endothelial Impairment in Ovariectomized Hyperhomocysteinemic Rats. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-494103
American Medical Association (AMA)
Zhen, Panpan& Zhao, Qian& Hou, Dandan& Liu, Teng& Jiang, Dongqiao& Duan, Jinhong…[et al.]. Genistein Attenuates Vascular Endothelial Impairment in Ovariectomized Hyperhomocysteinemic Rats. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-494103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494103