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Lovastatin as an Adjuvant to Lithium for Treating Manic Phase of Bipolar Disorder : A 4-Week, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Joint Authors
Ghanizadeh, Ahmad
Shafiee, Sara
Javadpour, Ali
OmraniSigaroodi, Motahhar
Dabbaghmanesh, Mohammad Hossein
Source
Depression Research and Treatment
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
Many patients with bipolar disorder suffer from metabolic disorder.
Lovastatin is effective for treating major depression.
This double-blind randomized placebo controlled clinical trial investigates whether lovastatin is a useful adjuvant to lithium for treating mania.
Methods.
Fifty-four patients with bipolar disorder-manic phase were randomly allocated into lovastatin or placebo group.
The clinical symptoms were assessed at baseline, week 2, and week 4 using Young Mania Rating Scale.
Adverse effects were checked.
Results.
Forty-six out of 54 patients completed this trial.
The mania score in the lovastatin group decreased from 40.6 (11.1) at baseline to 12.9 (8.7) and 4.1 (5.4) at weeks 2 and 4, respectively.
The score in the placebo group decreased from 41.0 (11.2) at baseline to 12.8 (8.07) and 5.8 (4.6) at weeks 2 and 4, respectively.
However, there was no significant difference between groups at week 2 and week 4.
The adverse effects rates were comparable between the two groups.
No serious adverse effect was found.
Tremor and nausea were the most common adverse effects.
Conclusions.
Lovastatin neither exacerbated nor decreased the symptoms of mania in patients with bipolar disorder.
Current results support that the combination of lovastatin with lithium is tolerated well in bipolar disorder.
The trial was registered with the Iranian Clinical Trials Registry (IRCT201302203930N18).
American Psychological Association (APA)
Ghanizadeh, Ahmad& OmraniSigaroodi, Motahhar& Javadpour, Ali& Dabbaghmanesh, Mohammad Hossein& Shafiee, Sara. 2014. Lovastatin as an Adjuvant to Lithium for Treating Manic Phase of Bipolar Disorder : A 4-Week, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Depression Research and Treatment،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-494109
Modern Language Association (MLA)
Ghanizadeh, Ahmad…[et al.]. Lovastatin as an Adjuvant to Lithium for Treating Manic Phase of Bipolar Disorder : A 4-Week, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Depression Research and Treatment No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-494109
American Medical Association (AMA)
Ghanizadeh, Ahmad& OmraniSigaroodi, Motahhar& Javadpour, Ali& Dabbaghmanesh, Mohammad Hossein& Shafiee, Sara. Lovastatin as an Adjuvant to Lithium for Treating Manic Phase of Bipolar Disorder : A 4-Week, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Depression Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-494109
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494109