Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers
Joint Authors
Liu, Songcan
Gao, Chenglu
Zhu, Leilei
He, Min
Ma, Yueming
Jiang, Jian
Zhang, Liang
Qiu, Fu-rong
Ye, Yujie
Miao, Ping
Li, Qiuye
Zhang, Xinfeng
Wang, Guangji
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to investigate the effect of single- and multidose administration of the ethanol extract of danshen on in vivo CYP3A activity in healthy volunteers.
A sequential, open-label, and three-period pharmacokinetic interaction study design was used based on 12 healthy male individuals.
The plasma concentrations of midazolam and its metabolite 1-hydroxymidazolam were measured.
Treatment with single dose of the extract caused the mean Cmax of midazolam to increase by 87% compared with control.
After 10 days of the danshen extract intake, the mean AUC0–12, Cmax, and t1/2 of midazolam were decreased by 79.9%, 66.6%, and 43.8%, respectively.
The mean clearance of midazolam was increased by 501.6% compared with control.
The in vitro study showed that dihydrotanshinone I in the extract could inhibit CYP3A, while tanshinone IIA and cryptotanshinone could induce CYP3A.
In conclusion, a single-dose administration of the danshen extract can inhibit intestinal CYP3A, but multidose administration can induce intestinal and hepatic CYP3A.
American Psychological Association (APA)
Qiu, Fu-rong& Jiang, Jian& Ma, Yueming& Wang, Guangji& Gao, Chenglu& Zhang, Xinfeng…[et al.]. 2013. Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-494138
Modern Language Association (MLA)
Qiu, Fu-rong…[et al.]. Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-494138
American Medical Association (AMA)
Qiu, Fu-rong& Jiang, Jian& Ma, Yueming& Wang, Guangji& Gao, Chenglu& Zhang, Xinfeng…[et al.]. Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-494138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494138