Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary Müllerian Tissues
Joint Authors
Chen, Ren
Drenberg, Christina D.
Kruk, Patricia A.
Livingston, Sandra
Nicosia, Santo V.
Source
Obstetrics and Gynecology International
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
While semaphorins and their receptors appear to play a role in tumor carcinogenesis, little is known about the role of semaphorin 3F (S3F) in epithelial ovarian cancer (EOC) development.
Therefore, we sought to determine the clinical relationship between S3F and its receptors, neuropilin-2 (NP-2) and neuropilin-1 (NP-1) with EOC progression.
We analyzed the immunohistological expression of S3F, NP-2, and NP-1 in clinical specimens of normal ovaries (N), benign cystadenomas (Cy), well-differentiated adenocarcinomas (WD), poorly-differentiated adenocarcinomas (PD), inclusion cysts (IC), paraovarian cysts (PC), and fallopian tubes (FT).
Tissue sections were evaluated for staining intensity and percentage of immunoreactive epithelia.
We found that expression of S3F and NP-2 decreased while NP-1 expression increased with EOC progression.
Interestingly, we also found elevated expression of S3F, NP-2, and NP-1 in epithelia of ICs, PCs, and FT.
Our findings indicate that loss or deregulation of semaphorin signaling may play an important role in EOC development.
American Psychological Association (APA)
Drenberg, Christina D.& Livingston, Sandra& Chen, Ren& Kruk, Patricia A.& Nicosia, Santo V.. 2009. Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary Müllerian Tissues. Obstetrics and Gynecology International،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-494139
Modern Language Association (MLA)
Drenberg, Christina D.…[et al.]. Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary Müllerian Tissues. Obstetrics and Gynecology International No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-494139
American Medical Association (AMA)
Drenberg, Christina D.& Livingston, Sandra& Chen, Ren& Kruk, Patricia A.& Nicosia, Santo V.. Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary Müllerian Tissues. Obstetrics and Gynecology International. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-494139
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494139