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Progesterone Withdrawal-Evoked Plasticity of Neural Function in the Female Periaqueductal Grey Matter
Joint Authors
Lovick, Thelma A.
Devall, A. J.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-12-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cyclical changes in production of neuroactive steroids during the oestrous cycle induce significant changes in GABAA receptor expression in female rats.
In the periaqueductal grey (PAG) matter, upregulation of α4β1δ GABAA receptors occurs as progesterone levels fall during late dioestrus (LD) or during withdrawal from an exogenous progesterone dosing regime.
The new receptors are likely to be extrasynaptically located on the GABAergic interneurone population and to mediate tonic currents.
Electrophysiological studies showed that when α4β1δ GABAA receptor expression was increased, the excitability of the output neurones in the PAG increased, due to a decrease in the level of ongoing inhibitory tone from the GABAergic interneurones.
The functional consequences in terms of nociceptive processing were investigated in conscious rats.
Baseline tail flick latencies were similar in all rats.
However, acute exposure to mild vibration stress evoked hyperalgesia in rats in LD and after progesterone withdrawal, in line with the upregulation of α4β1δ GABAA receptor expression.
American Psychological Association (APA)
Lovick, Thelma A.& Devall, A. J.. 2008. Progesterone Withdrawal-Evoked Plasticity of Neural Function in the Female Periaqueductal Grey Matter. Neural Plasticity،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-494163
Modern Language Association (MLA)
Lovick, Thelma A.& Devall, A. J.. Progesterone Withdrawal-Evoked Plasticity of Neural Function in the Female Periaqueductal Grey Matter. Neural Plasticity No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-494163
American Medical Association (AMA)
Lovick, Thelma A.& Devall, A. J.. Progesterone Withdrawal-Evoked Plasticity of Neural Function in the Female Periaqueductal Grey Matter. Neural Plasticity. 2008. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-494163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494163