Relationship between EGF, TGFA, and EGFR Gene Polymorphisms and Traditional Chinese Medicine ZHENG in Gastric Cancer
Joint Authors
Yang, Yaping
Zhang, Chunbing
Yang, Xuewen
Dong, Wei
Tong, Shujuan
Zhang, Junfeng
Zhen, Zhang
Wu, Juan
Chen, Yajun
Wang, Ruiping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In traditional Chinese medicine (TCM), correct syndrome differentiation is the most important principle guiding the prescription of Chinese herbal formulae for the treatment of gastric cancer (GC).
We aimed to reveal the genetic mechanisms underlying GC syndrome differentiation (ZHENG) in a population of 387 GC patients.
Twenty-nine single nucleotide polymorphisms (SNPs) in EGF, TGFA, and EGFR were investigated.
Two SNPs, rs11466285 in TGFA and rs884225 in EGFR, were significantly associated with the distribution of ZHENG (P<0.05).
The rs11466285 TT genotype increased the risk of damp heat with toxin (DHT) and deficiency of both Qi and yin (DQY) compared with obstruction of blood stasis (OBS).
The rs884225 AA genotype could increase the risk of DQY and deficiency of both Qi and blood (DQB) compared with yin deficiency due to stomach heat (YDSH).
Parallel comparison among the SNPs and syndrome types revealed that DQB was distinct from YDSH, disharmony between the liver and stomach, stagnation of phlegm muddiness (SPM), OBS, and other syndromes at several SNP loci (P<0.05).
The rs11466285 TT and rs884225 AA genotypes exhibit increased risk of DQB compared with OBS and SPM (P<0.05), respectively.
In conclusion, the formation of GC ZHENG was related to EGF, TGFA, and EGFR gene polymorphisms.
American Psychological Association (APA)
Zhang, Junfeng& Zhen, Zhang& Wu, Juan& Zhang, Chunbing& Yang, Yaping& Tong, Shujuan…[et al.]. 2013. Relationship between EGF, TGFA, and EGFR Gene Polymorphisms and Traditional Chinese Medicine ZHENG in Gastric Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-494183
Modern Language Association (MLA)
Zhang, Junfeng…[et al.]. Relationship between EGF, TGFA, and EGFR Gene Polymorphisms and Traditional Chinese Medicine ZHENG in Gastric Cancer. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-494183
American Medical Association (AMA)
Zhang, Junfeng& Zhen, Zhang& Wu, Juan& Zhang, Chunbing& Yang, Yaping& Tong, Shujuan…[et al.]. Relationship between EGF, TGFA, and EGFR Gene Polymorphisms and Traditional Chinese Medicine ZHENG in Gastric Cancer. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-494183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494183