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Structurally Diverse Metal Coordination Compounds, Bearing Imidodiphosphinate and Diphosphinoamine Ligands, as Potential Inhibitors of the Platelet Activating Factor
Joint Authors
Tsoupras, Alexandros B.
Roulia, Maria
Ferentinos, Eleftherios
Demopoulos, Constantinos A.
Kyritsis, Panayotis
Stamatopoulos, Ioannis
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Metal complexes bearing dichalcogenated imidodiphosphinate [R2P(E)NP(E)R2′]- ligands (E = O, S, Se, Te), which act as (E,E) chelates, exhibit a remarkable variety of three-dimensional structures.
A series of such complexes, namely, square-planar [Cu{(OPPh2)(OPPh2)N-O,O}2], tetrahedral [Zn{(EPPh2)(EPPh2)N-E,E}2], E = O, S, and octahedral [Ga{(OPPh2)(OPPh2)N-O,O}3], were tested as potential inhibitors of either the platelet activating factor (PAF)- or thrombin-induced aggregation in both washed rabbit platelets and rabbit platelet rich plasma.
For comparison, square-planar [Ni{(Ph2P)2N-S-CHMePh-P,P}X2], X = Cl, Br, the corresponding metal salts of all complexes and the (OPPh2)(OPPh2)NH ligand were also investigated.
Ga(O,O)3 showed the highest anti-PAF activity but did not inhibit the thrombin-related pathway, whereas Zn(S,S)2, with also a significant PAF inhibitory effect, exhibited the highest thrombin-related inhibition.
Zn(O,O)2 and Cu(O,O)2 inhibited moderately both PAF and thrombin, being more effective towards PAF.
This work shows that the PAF-inhibitory action depends on the structure of the complexes studied, with the bulkier Ga(O,O)3 being the most efficient and selective inhibitor.
American Psychological Association (APA)
Tsoupras, Alexandros B.& Roulia, Maria& Ferentinos, Eleftherios& Stamatopoulos, Ioannis& Demopoulos, Constantinos A.& Kyritsis, Panayotis. 2010. Structurally Diverse Metal Coordination Compounds, Bearing Imidodiphosphinate and Diphosphinoamine Ligands, as Potential Inhibitors of the Platelet Activating Factor. Bioinorganic Chemistry and Applications،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-494189
Modern Language Association (MLA)
Tsoupras, Alexandros B.…[et al.]. Structurally Diverse Metal Coordination Compounds, Bearing Imidodiphosphinate and Diphosphinoamine Ligands, as Potential Inhibitors of the Platelet Activating Factor. Bioinorganic Chemistry and Applications No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-494189
American Medical Association (AMA)
Tsoupras, Alexandros B.& Roulia, Maria& Ferentinos, Eleftherios& Stamatopoulos, Ioannis& Demopoulos, Constantinos A.& Kyritsis, Panayotis. Structurally Diverse Metal Coordination Compounds, Bearing Imidodiphosphinate and Diphosphinoamine Ligands, as Potential Inhibitors of the Platelet Activating Factor. Bioinorganic Chemistry and Applications. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-494189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494189