Resistance to Erythropoiesis-Stimulating Agents Is Associated with Arterial Microcalcification in Early Hemodialysis Patients
Joint Authors
Shin, Ok-Ran
Kim, Young Soo
Ko, Yoon Ho
Choi, Su Jin
Kim, Young Ok
Won, Hye Sung
Yoon, Sun Ae
Yun, Yu Seon
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this study was to evaluate the relationship between arterial microcalcification (AMiC) and erythropoiesis-stimulating agents (ESA) hyporesponsiveness in hemodialysis patients.
The presence of AMiC was confirmed by pathologic examination of von Kossa-stained arterial specimens acquired during vascular access surgery.
We assessed the ESA hyporesponsiveness index (EHRI), defined as the weekly ESA dose per kilogram body weight divided by the hemoglobin level.
AMiC was detected in 33 (40.2%) of 82 patients.
Patients with diabetes had a higher incidence of AMiC than patients without diabetes.
The serum levels of albumin and cholesterol were higher in patients without AMiC than in patients with AMiC.
The serum levels of intact parathyroid hormone were lower in patients with AMiC than in patients without AMiC.
The serum levels of phosphate and calcium-phosphorus product did not differ between the two groups.
The mean EHRI value was higher in patients with AMiC than in patients without AMiC.
In multivariate analyses, ESA hyporesponsiveness and diabetes showed a significant association with AMiC.
In conclusion, ESA hyporesponsiveness may be a clinical relevant parameters related to AMiC in hemodialysis patients.
American Psychological Association (APA)
Won, Hye Sung& Choi, Su Jin& Yun, Yu Seon& Shin, Ok-Ran& Ko, Yoon Ho& Kim, Young Soo…[et al.]. 2014. Resistance to Erythropoiesis-Stimulating Agents Is Associated with Arterial Microcalcification in Early Hemodialysis Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-494196
Modern Language Association (MLA)
Won, Hye Sung…[et al.]. Resistance to Erythropoiesis-Stimulating Agents Is Associated with Arterial Microcalcification in Early Hemodialysis Patients. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-494196
American Medical Association (AMA)
Won, Hye Sung& Choi, Su Jin& Yun, Yu Seon& Shin, Ok-Ran& Ko, Yoon Ho& Kim, Young Soo…[et al.]. Resistance to Erythropoiesis-Stimulating Agents Is Associated with Arterial Microcalcification in Early Hemodialysis Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-494196
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494196