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Role of oxidative stress in cisplatin-induced nephrotoxicity in rats
Other Title(s)
دور جهد الأكسدة في السمية المحدثة بعقار السيسبلاتين على كلى الفئران
Joint Authors
Umran, Fatin Muhammad
Ahmad, Najwa Sayyid
Abd al-Aziz, Muhammad Anwar
Muhammad, Duha Sabir
Source
Issue
Vol. 30, Issue 1 (31 Jan. 2006), pp.117-130, 14 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2006-01-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Topics
Abstract EN
Cisplatin (cis diammine dichloroplatinum) is a potent antitumor drug.
Expansion of the clinical utility of cisplatin has been limited by its toxicity where acute and chronic forms of renal injury have been described due to apoptosis.
The mechanism by which it activates the myriad of apoptotic pathways remains unclear.
Several studies have now documented the importance of reactive oxygen metabolites (ROM) in cisplatin-induced renal cell apoptosis.
To further clarify this point the present study was conducted to evaluate the oxidative stress induced by cisplatin.
Rats were treated either by high single interaperiotoneal dose (7mg/kg) or by repeated small doses (4mg/kg) twice weekly for one month.
Rats were sacrificed by decapitation after 48 hours of high dose intake or 24 hours after intake repeated small doses.
Kidney tissues were removed for histopathological examination, after homogenization these tissues were removedfor determination of glutathione (GSH).
Blood samples were taken from rats for determination of serum level of creatinine, blood urea nitrogen (BUN) and nitric oxide (NO).
Histopathological examination of kidney tissue revealed degenerative changes with tubular change, especially in the proximal convoluted tubules.
Significant elevation in serum creatinine (2.24±0.18 vs 2.12±0.18) and BUN (146±10.6 vsl32±I 1.2) levels were observed.
Administration of cisplatin in large dose or.
small repeated doses causes significant elevation in serum (NO) level (10.4±0.8 pmoUl and 9±0.53 p.mol/1 respectively) as well as depletion in renal (GSH) tissue levels (1:02±0.09 pmol/g w.wt (wet, weight) and 1.12 ± 0.08 fimol/g w.wt, respectively).
From these results, it can be concluded that single high dose or small repeated doses of cisplatin-induced nephrotoxicity was associated with induction of oxidative stress.
Use of antioxidants in conjunction with cisplatin could be a value in minimizing its toxicity.
American Psychological Association (APA)
Umran, Fatin Muhammad& Ahmad, Najwa Sayyid& Abd al-Aziz, Muhammad Anwar& Muhammad, Duha Sabir. 2006. Role of oxidative stress in cisplatin-induced nephrotoxicity in rats. Assiut Medical Journal،Vol. 30, no. 1, pp.117-130.
https://search.emarefa.net/detail/BIM-49421
Modern Language Association (MLA)
Umran, Fatin Muhammad…[et al.]. Role of oxidative stress in cisplatin-induced nephrotoxicity in rats. Assiut Medical Journal Vol. 30, no. 1(January 2006), pp.117-130.
https://search.emarefa.net/detail/BIM-49421
American Medical Association (AMA)
Umran, Fatin Muhammad& Ahmad, Najwa Sayyid& Abd al-Aziz, Muhammad Anwar& Muhammad, Duha Sabir. Role of oxidative stress in cisplatin-induced nephrotoxicity in rats. Assiut Medical Journal. 2006. Vol. 30, no. 1, pp.117-130.
https://search.emarefa.net/detail/BIM-49421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 129-130
Record ID
BIM-49421