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Cytokines and Growth Factors Promote Airway Smooth Muscle Cell Proliferation
Joint Authors
Hatziefthimiou, A.
Gourgoulianis, K. I.
Paraskeva, E.
Molyvdas, P.-A.
Stamatiou, R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Chronic airway diseases, such as asthma or chronic obstructive pulmonary disease, are characterized by the presence in the airways of inflammation factors, growth factors and cytokines, which promote airway wall remodelling.
The aim of this study was to investigate the effect of cytokines and growth factors on airway smooth muscle cell (ASMC) proliferation, phenotype and responsiveness.
Incubation of serum starved human bronchial ASMCs with TNF-α, TGF, bFGF, and PDGF, but not IL-1β, increased methyl-[3H]thymidine incorporation and cell number, mediated by the PI3K and MAPK signalling pathways.
Regarding rabbit tracheal ASMC proliferation, TNF-α, IL-1β, TGF, and PDGF increased methyl-[3H]thymidine incorporation in a PI3K- and MAPK-dependent manner.
bFGF increased both methyl-[3H]thymidine incorporation and cell number.
Moreover, incubation with TGF, bFGF and PDGF appears to drive human ASMCs towards a synthetic phenotype, as shown by the reduction of the percentage of cells expressing SM-α actin.
In addition, the responsiveness of epithelium-denuded rabbit tracheal strips to carbachol was not significantly altered after 3-day treatment with bFGF.
In conclusion, all the tested cytokines and growth factors increased ASMC proliferation to a different degree, depending on the specific cell type, with bronchial ASMCs being more prone to proliferation than tracheal ASMCs.
American Psychological Association (APA)
Stamatiou, R.& Paraskeva, E.& Gourgoulianis, K. I.& Molyvdas, P.-A.& Hatziefthimiou, A.. 2013. Cytokines and Growth Factors Promote Airway Smooth Muscle Cell Proliferation. ISRN Inflammation،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-494212
Modern Language Association (MLA)
Stamatiou, R.…[et al.]. Cytokines and Growth Factors Promote Airway Smooth Muscle Cell Proliferation. ISRN Inflammation No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-494212
American Medical Association (AMA)
Stamatiou, R.& Paraskeva, E.& Gourgoulianis, K. I.& Molyvdas, P.-A.& Hatziefthimiou, A.. Cytokines and Growth Factors Promote Airway Smooth Muscle Cell Proliferation. ISRN Inflammation. 2013. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-494212
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494212