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Aquaporin Expression in Normal and Pathological Skeletal Muscles : A Brief Review with Focus on AQP4
Author
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Freeze-fracture electron microscopy enabled us to observe the molecular architecture of the biological membranes.
We were studying the myofiber plasma membranes of health and disease by using this technique and were interested in the special assembly called orthogonal arrays (OAs).
OAs were present in normal myofiber plasma membranes and were especially numerous in fast twitch type 2 myofibers; while OAs were lost from sarcolemmal plasma membranes of severely affected muscles with dystrophinopathy and dysferlinopathy but not with caveolinopathy.
In the mid nineties of the last century, the OAs turned out to be a water channel named aquaporin 4 (AQP4).
Since this discovery, several groups of investigators have been studying AQP4 expression in diseased muscles.
This review summarizes the papers which describe the expression of OAs, AQP4, and other AQPs at the sarcolemma of healthy and diseased muscle and discusses the possible role of AQPs, especially that of AQP4, in normal and pathological skeletal muscles.
American Psychological Association (APA)
Wakayama, Yoshihiro. 2010. Aquaporin Expression in Normal and Pathological Skeletal Muscles : A Brief Review with Focus on AQP4. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-494227
Modern Language Association (MLA)
Wakayama, Yoshihiro. Aquaporin Expression in Normal and Pathological Skeletal Muscles : A Brief Review with Focus on AQP4. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-494227
American Medical Association (AMA)
Wakayama, Yoshihiro. Aquaporin Expression in Normal and Pathological Skeletal Muscles : A Brief Review with Focus on AQP4. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-494227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494227