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Metabolomics Network Characterization of Resuscitation after Normocapnic Hypoxia in a Newborn Piglet Model Supports the Hypothesis That Room Air Is Better
Joint Authors
d'Aloja, E.
Murgia, F.
Noto, A.
Xanthos, Theodoros
Lussu, M.
Barberini, Luigi
Atzori, L.
Iacovidou, Nicoletta
Fanos, Vassilios
Finco, G.
Papalois, Apostolos E.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Perinatal asphyxia is attributed to hypoxia and/or ischemia around the time of birth and may lead to multiorgan dysfunction.
Aim of this research article is to investigate whether different metabolomic profiles occurred according to oxygen concentration administered at resuscitation.
In order to perform the experiment, forty newborn piglets were subjected to normocapnic hypoxia and reoxygenation and were randomly allocated in 4 groups resuscitated with different oxygen concentrations, 18%, 21%, 40%, and 100%, respectively.
Urine metabolic profiles at baseline and at hypoxia were analysed by 1H-NMR spectroscopy and metabolites were also identified by multivariate statistical analysis.
Metabolic pathways associations were also built up by ingenuity pathway analysis (IPA).
Bioinformatics analysis of metabolites characterized the effect of metabolism in the 4 groups; it showed that the 21% of oxygen is the most “physiological” and appropriate concentration to be used for resuscitation.
Our data indicate that resuscitation with 21% of oxygen seems to be optimal in terms of survival, rapidity of resuscitation, and metabolic profile in the present animal model.
These findings need to be confirmed with metabolomics in human and, if so, the knowledge of the perinatal asphyxia condition may significantly improve.
American Psychological Association (APA)
Fanos, Vassilios& Noto, A.& Xanthos, Theodoros& Lussu, M.& Murgia, F.& Barberini, Luigi…[et al.]. 2014. Metabolomics Network Characterization of Resuscitation after Normocapnic Hypoxia in a Newborn Piglet Model Supports the Hypothesis That Room Air Is Better. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-494237
Modern Language Association (MLA)
Fanos, Vassilios…[et al.]. Metabolomics Network Characterization of Resuscitation after Normocapnic Hypoxia in a Newborn Piglet Model Supports the Hypothesis That Room Air Is Better. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-494237
American Medical Association (AMA)
Fanos, Vassilios& Noto, A.& Xanthos, Theodoros& Lussu, M.& Murgia, F.& Barberini, Luigi…[et al.]. Metabolomics Network Characterization of Resuscitation after Normocapnic Hypoxia in a Newborn Piglet Model Supports the Hypothesis That Room Air Is Better. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-494237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494237