Effects of Hydrogen-Rich Saline on Taurocholate-Induced Acute Pancreatitis in Rat
Joint Authors
Chen, Wei-chang
Feng, Huang
Zhang, De-qing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Oxidative stress plays an important role in the pathogenesis of acute pancreatitis (AP).
As an ideal exterminator of poisonous free radicals, hydrogen can clearly reduce the degree of oxidative damage caused by severe acute pancreatitis (SAP) and lessen the presence of inflammatory cytokines.
The aim of this study was to investigate the effects and mechanism of hydrogen-rich saline on SAP in rats.
Serum TNF-α, IL-6, and IL-18 and histopathological score in the pancreas were reduced after hydrogen-rich saline treatment.
Malondialdehyde (MDA) and myeloperoxidase (MPO) contents were obviously reduced, while superoxide dismutase (SOD) and glutathione (GSH) contents were increased after hydrogen-rich saline treatment.
The expression of mRNA of tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1) in the pancreas was reduced in hydrogen-rich saline treated group.
In conclusion, intravenous hydrogen-rich saline injections could attenuate the severity of AP, probably via inhibiting the oxidative stress and reducing the presence of inflammatory mediators.
American Psychological Association (APA)
Zhang, De-qing& Feng, Huang& Chen, Wei-chang. 2013. Effects of Hydrogen-Rich Saline on Taurocholate-Induced Acute Pancreatitis in Rat. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-494263
Modern Language Association (MLA)
Zhang, De-qing…[et al.]. Effects of Hydrogen-Rich Saline on Taurocholate-Induced Acute Pancreatitis in Rat. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-494263
American Medical Association (AMA)
Zhang, De-qing& Feng, Huang& Chen, Wei-chang. Effects of Hydrogen-Rich Saline on Taurocholate-Induced Acute Pancreatitis in Rat. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-494263
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494263