![](/images/graphics-bg.png)
Polyphenols Isolated from Propolis Augment TRAIL-Induced Apoptosis in Cancer Cells
Joint Authors
Szliszka, Ewelina
Krol, Wojciech
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Epidemiological data support the concept that phenols and polyphenols in diet are safe and nontoxic, and have long-lasting beneficial effects on human health.
The potential target for complementary and alternative medicine (CAM) research has been on the discovery of natural compounds that can be used in the prevention and treatment of cancer.
Propolis is one of the richest sources of plant phenolics (flavonoids and phenolic acids).
The ethanolic extract of propolis (EEP) and its polyphenols possess immunomodulatory, chemopreventive, and antitumor effects.
Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a naturally occurring anticancer agent that preferentially induces apoptosis in cancer cells and is not toxic to normal cells.
Endogenous TRAIL plays a significant role in immunosurveillance and defense against cancer cells.
However, as more tumor cells are reported to be resistant to TRAIL-mediated death, it is important to develop new strategies to overcome this resistance.
EEP and polyphenols isolated from propolis have been shown to sensitize cancer cells to TRAIL-induced apoptosis.
In this paper we demonstrate for the first time the crucial role of the main phenolics isolated from propolis in enhancing TRAIL-mediated death in tumor cells for cancer chemoprevention.
American Psychological Association (APA)
Szliszka, Ewelina& Krol, Wojciech. 2013. Polyphenols Isolated from Propolis Augment TRAIL-Induced Apoptosis in Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-494265
Modern Language Association (MLA)
Szliszka, Ewelina& Krol, Wojciech. Polyphenols Isolated from Propolis Augment TRAIL-Induced Apoptosis in Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-494265
American Medical Association (AMA)
Szliszka, Ewelina& Krol, Wojciech. Polyphenols Isolated from Propolis Augment TRAIL-Induced Apoptosis in Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-494265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494265