Pathological Importance of the Endothelin-1ETB Receptor System on Vascular Diseases
Joint Authors
Ohkita, Mamoru
Matsumura, Yasuo
Kitada, Kento
Source
Cardiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Activation of the endothelin (ET)-1/ET receptor system is involved in the development of vascular diseases such as atherosclerosis, vascular hypertrophy, and restenosis.
Some issues still remain unresolved including whether ET receptor antagonists are expected to become the new therapeutic tools for the treatment of vascular diseases.
One of the unresolved critical points is the functional role of ET receptor subtypes on each vascular disease, in particular the pathophysiological roles of the ETB receptor.
We recently demonstrated that selective inhibition of the ETB receptor system showed harmful effects in the development of neointimal formation after vascular injury.
However, there was no apparent difference in the therapeutic effects between a nonselective ETA/ETB receptor antagonist and selective ETA receptor antagonist.
These findings indicate that antagonism of the ETA receptor system is essential for suppressing vascular remodeling, irrespective of the presence of ETB-receptor-mediated actions, although the selective ETB receptor antagonist worsens vascular remodeling.
In addition, we found that ET receptor systems contribute to sex differences in the severity of vascular disease, thereby suggesting that the efficacy of ET receptor antagonists for vascular diseases may differ between sexes.
In this paper, we outline the roles of the ET-1/ETB receptor system on vascular diseases and its sex differences.
American Psychological Association (APA)
Kitada, Kento& Ohkita, Mamoru& Matsumura, Yasuo. 2012. Pathological Importance of the Endothelin-1ETB Receptor System on Vascular Diseases. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-494268
Modern Language Association (MLA)
Kitada, Kento…[et al.]. Pathological Importance of the Endothelin-1ETB Receptor System on Vascular Diseases. Cardiology Research and Practice No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-494268
American Medical Association (AMA)
Kitada, Kento& Ohkita, Mamoru& Matsumura, Yasuo. Pathological Importance of the Endothelin-1ETB Receptor System on Vascular Diseases. Cardiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-494268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494268