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Interaction of Veratrum nigrum with Panax ginseng against Obesity : A Sang-ban Relationship
Joint Authors
Jeon, Yong-Deok
Kim, Hye-Lin
Park, Jinbong
Kim, Hyun-Ju
Lim, Hara
Jeong, Mi-Young
Kim, Su-Jin
Um, Jae-Young
Hong, Seung-Heon
Kim, Sung-Hoon
Youn, Dong-Hyun
Jung, Yunu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Obesity has become a major health threat in developed countries.
However, current medications for obesity are limited because of their adverse effects.
Interest in natural products for the treatment of obesity is thus rapidly growing.
Korean Medicine (KM) is characterized by the wide use of herbal formulas.
However, the combination rule of herbal formulas in KM lacks experimental evidence.
According to Shennong’s Classic of Materia Medica, the earliest book of herbal medicine, Veratrum nigrum (VN) has antagonistic features against Panax ginseng (PG), and the PG-VN pair is strictly forbidden.
In this study, we have shown the effects of PG, VN, and their combination on obesity in high-fat (HF) diet-induced obese mice and in 3T3-L1 cells.
PG, VN, and PG-VN combination significantly reduced weight gain and the fat pad weight in HF diet-induced obese mice.
They also significantly decreased lipid accumulation and the expressions of two major adipogenesis factors, PPARγ and C/EBPα, in 3T3-L1 cells.
In addition, the PG-VN combination had synergistic effects compared with the mixture of extracts of PG and VN on inhibition of PPARγ and C/EBPα expressions at lower doses.
These results indicate a new potential anti-obese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in KM.
American Psychological Association (APA)
Park, Jinbong& Jeon, Yong-Deok& Kim, Hye-Lin& Lim, Hara& Jung, Yunu& Youn, Dong-Hyun…[et al.]. 2013. Interaction of Veratrum nigrum with Panax ginseng against Obesity : A Sang-ban Relationship. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-494284
Modern Language Association (MLA)
Park, Jinbong…[et al.]. Interaction of Veratrum nigrum with Panax ginseng against Obesity : A Sang-ban Relationship. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-494284
American Medical Association (AMA)
Park, Jinbong& Jeon, Yong-Deok& Kim, Hye-Lin& Lim, Hara& Jung, Yunu& Youn, Dong-Hyun…[et al.]. Interaction of Veratrum nigrum with Panax ginseng against Obesity : A Sang-ban Relationship. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-494284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494284