Challenges in Immunotherapy Presented by the Glioblastoma Multiforme Microenvironment
Joint Authors
Jackson, Christopher
Lim, Michael
Belcaid, Zineb
Ruzevick, Jacob
Phallen, Jillian
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-10
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults.
Despite intensive treatment, the prognosis for patients with GBM remains grim with a median survival of only 14.6 months.
Immunotherapy has emerged as a promising approach for treating many cancers and affords the advantages of cellular-level specificity and the potential to generate durable immune surveillance.
The complexity of the tumor microenvironment poses a significant challenge to the development of immunotherapy for GBM, as multiple signaling pathways, cytokines, and cell types are intricately coordinated to generate an immunosuppressive milieu.
The development of new immunotherapy approaches frequently uncovers new mechanisms of tumor-mediated immunosuppression.
In this review, we discuss many of the current approaches to immunotherapy and focus on the challenges presented by the tumor microenvironment.
American Psychological Association (APA)
Jackson, Christopher& Ruzevick, Jacob& Phallen, Jillian& Belcaid, Zineb& Lim, Michael. 2011. Challenges in Immunotherapy Presented by the Glioblastoma Multiforme Microenvironment. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-20.
https://search.emarefa.net/detail/BIM-494299
Modern Language Association (MLA)
Jackson, Christopher…[et al.]. Challenges in Immunotherapy Presented by the Glioblastoma Multiforme Microenvironment. Clinical and Developmental Immunology No. 2011 (2011), pp.1-20.
https://search.emarefa.net/detail/BIM-494299
American Medical Association (AMA)
Jackson, Christopher& Ruzevick, Jacob& Phallen, Jillian& Belcaid, Zineb& Lim, Michael. Challenges in Immunotherapy Presented by the Glioblastoma Multiforme Microenvironment. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-20.
https://search.emarefa.net/detail/BIM-494299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494299