Identification of Differentially Expressed MicroRNAs in Osteosarcoma
Joint Authors
Bischof, Jared M.
Soares, Marcelo B.
Costa, Fabricio F.
Lulla, Rishi R.
Chou, Pauline M.
Bonaldo, Maria de Fatima
Vanin, Elio F.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A limited number of reports have investigated the role of microRNAs in osteosarcoma.
In this study, we performed miRNA expression profiling of osteosarcoma cell lines, tumor samples, and normal human osteoblasts.
Twenty-two differentially expressed microRNAs were identified using high throughput real-time PCR analysis, and 4 (miR-135b, miR-150, miR-542-5p, and miR-652) were confirmed and validated in a different group of tumors.
Both miR-135b and miR-150 have been previously shown to be important in cancer.
We hypothesize that dysregulation of differentially expressed microRNAs may contribute to tumorigenesis.
They might also represent molecular biomarkers or targets for drug development in osteosarcoma.
American Psychological Association (APA)
Lulla, Rishi R.& Costa, Fabricio F.& Bischof, Jared M.& Chou, Pauline M.& Bonaldo, Maria de Fatima& Vanin, Elio F.…[et al.]. 2011. Identification of Differentially Expressed MicroRNAs in Osteosarcoma. Sarcoma،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494328
Modern Language Association (MLA)
Lulla, Rishi R.…[et al.]. Identification of Differentially Expressed MicroRNAs in Osteosarcoma. Sarcoma No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-494328
American Medical Association (AMA)
Lulla, Rishi R.& Costa, Fabricio F.& Bischof, Jared M.& Chou, Pauline M.& Bonaldo, Maria de Fatima& Vanin, Elio F.…[et al.]. Identification of Differentially Expressed MicroRNAs in Osteosarcoma. Sarcoma. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494328
