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Hyponatremia and Congestive Heart Failure : A Marker of Increased Mortality and a Target for Therapy
Joint Authors
Romanovsky, Adam
Rosner, Mitchell H.
Bagshaw, Sean
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Heart failure is one of the most common chronic medical conditions in the developed world.
It is characterized by neurohormonal activation of multiple systems that can lead to clinical deterioration and significant morbidity and mortality.
In this regard, hyponatremia is due to inappropriate and continued vasopressin activity despite hypoosmolality and volume overload.
Hyponatremia is also due to diuretic use in an attempt to manage volume overload.
When hyponatremia occurs, it is a marker of heart failure severity and identifies patients with increased mortality.
The recent introduction of specific vasopressin-receptor antagonists offers a targeted pharmacological approach to these pathophysiological derangements.
Thus far, clinical trials with vasopressin-receptor antagonists have demonstrated an increase in free-water excretion, improvement in serum sodium, modest improvements in dyspnea but no improvement in mortality.
Continued clinical trials with these agents are needed to determine their specific role in the treatment of both chronic and decompensated heart failure.
American Psychological Association (APA)
Romanovsky, Adam& Bagshaw, Sean& Rosner, Mitchell H.. 2011. Hyponatremia and Congestive Heart Failure : A Marker of Increased Mortality and a Target for Therapy. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-494336
Modern Language Association (MLA)
Romanovsky, Adam…[et al.]. Hyponatremia and Congestive Heart Failure : A Marker of Increased Mortality and a Target for Therapy. International Journal of Nephrology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-494336
American Medical Association (AMA)
Romanovsky, Adam& Bagshaw, Sean& Rosner, Mitchell H.. Hyponatremia and Congestive Heart Failure : A Marker of Increased Mortality and a Target for Therapy. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-494336
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494336