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Repertoire Development and the Control of CytotoxicEffector Function in Human γδ T Cells
Joint Authors
Pauza, C. David
Chapoval, Andrei I.
Urban, Elizabeth M.
Source
Clinical and Developmental Immunology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
T cells develop into two major populations distinguished by their T cell receptor (TCR) chains.
Cells with the αβ TCR generally express CD4 or CD8 lineage markers and mostly fall into helper or cytotoxic/effector subsets.
Cells expressing the alternate γδ TCR in humans generally do not express lineage markers, do not require MHC for antigen presentation, and recognize nonpeptidic antigens.
We are interested in the dominant Vγ2Vδ2+ T cell subset in human peripheral blood and the control of effector function in this population.
We review the literature on γδ T cell generation and repertoire selection, along with recent work on CD56 expression and defining a cytotoxic/effector lineage within the phosphoantigen-reactive Vγ2Vδ2 cells.
A unique mechanism for MHC-independent repertoire selection is linked to the control of effector function that is vital to the role for γδ T cells in tumor surveillance.
Better understanding of these mechanisms will improve our ability to exploit this population for tumor immunotherapy.
American Psychological Association (APA)
Urban, Elizabeth M.& Chapoval, Andrei I.& Pauza, C. David. 2010. Repertoire Development and the Control of CytotoxicEffector Function in Human γδ T Cells. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-494356
Modern Language Association (MLA)
Urban, Elizabeth M.…[et al.]. Repertoire Development and the Control of CytotoxicEffector Function in Human γδ T Cells. Clinical and Developmental Immunology No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-494356
American Medical Association (AMA)
Urban, Elizabeth M.& Chapoval, Andrei I.& Pauza, C. David. Repertoire Development and the Control of CytotoxicEffector Function in Human γδ T Cells. Clinical and Developmental Immunology. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-494356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494356