Desipramine Pretreatment Improves Sympathetic Remodeling and Ventricular Fibrillation Threshold after Myocardial Ischemia
Joint Authors
Yu, Lilei
Liu, Wenwei
Hu, Xiaorong
Wu, Xiaolin
Jiang, Hong
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Abnormal increase in sympathetic nerve sprouting was responsible for the ventricular arrhythmogenesis after myocardial infarction.
This study investigated whether the norepinephrine transporter inhibitor, desipramine, can modulate sympathetic remodeling and ventricular fibrillation threshold (VFT) after myocardial ischemia-reperfusion.
Rats were administered desipramine (0.8 mg/kg, IV) before or after myocardial ischemia.
VFT, infarct size, tyrosine hydroxylase (TH) and growth-associated protein 43 (GAP43)-positive nerve fibers were measured after one week.
The VFT of preischemic treatment group was 11.0±2.65 V and significantly higher than that of control ischemic group (7.2±1.30 V, P<0.05).
Infarct size in the preischemic treatment group (23.3±2.4%) was significantly lower than that in the control ischemic group (30.8±1.3%, P<0.05) and the delayed application group (27.1±2.6%, P<0.05).
The density of TH and GAP43-positive nerve fibers in the control ischemic group was significantly higher than that in the other three groups (P<0.05).
The density of nerve fibers improved after desipramine treatment.
Moreover, there was a negative correlation between the VFT and both TH and GAP43-positive nerve fiber density in the infarct border zone (P<0.05).
Desipramine treatment before acute myocardial ischemia can decrease infarct size, improve sympathetic remodeling, and increase VFT and electrical stability of ischemic hearts.
Desipramine appears to cause myocardial ischemic preconditioning.
American Psychological Association (APA)
Wu, Xiaolin& Jiang, Hong& Yu, Lilei& Hu, Xiaorong& Liu, Wenwei. 2012. Desipramine Pretreatment Improves Sympathetic Remodeling and Ventricular Fibrillation Threshold after Myocardial Ischemia. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-494358
Modern Language Association (MLA)
Wu, Xiaolin…[et al.]. Desipramine Pretreatment Improves Sympathetic Remodeling and Ventricular Fibrillation Threshold after Myocardial Ischemia. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-494358
American Medical Association (AMA)
Wu, Xiaolin& Jiang, Hong& Yu, Lilei& Hu, Xiaorong& Liu, Wenwei. Desipramine Pretreatment Improves Sympathetic Remodeling and Ventricular Fibrillation Threshold after Myocardial Ischemia. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-494358
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494358