Impact of Endothelial Microparticles on Coagulation, Inflammation, and Angiogenesis in Age-Related Vascular Diseases
Joint Authors
Richard, Erin
Ludwicka-Bradley, Anna
Markiewicz, Margaret
Marks, Natalia
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Endothelial microparticles (EMPs) are complex vesicular structures that originate from plasma membranes of activated or apoptotic endothelial cells.
EMPs play a significant role in vascular function by altering the processes of inflammation, coagulation, and angiogenesis, and they are key players in the pathogenesis of several vascular diseases.
Circulating EMPs are increased in many age-related vascular diseases such as coronary artery disease, peripheral vascular disease, cerebral ischemia, and congestive heart failure.
Their elevation in plasma has been considered as both a biomarker and bioactive effector of vascular damage and a target for vascular diseases.
This review focuses on the pleiotropic roles of EMPs and the mechanisms that trigger their formation, particularly the involvement of decreased estrogen levels, thrombin, and PAI-1 as major factors that induce EMPs in age-related vascular diseases.
American Psychological Association (APA)
Markiewicz, Margaret& Richard, Erin& Marks, Natalia& Ludwicka-Bradley, Anna. 2013. Impact of Endothelial Microparticles on Coagulation, Inflammation, and Angiogenesis in Age-Related Vascular Diseases. Journal of Aging Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-494405
Modern Language Association (MLA)
Markiewicz, Margaret…[et al.]. Impact of Endothelial Microparticles on Coagulation, Inflammation, and Angiogenesis in Age-Related Vascular Diseases. Journal of Aging Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-494405
American Medical Association (AMA)
Markiewicz, Margaret& Richard, Erin& Marks, Natalia& Ludwicka-Bradley, Anna. Impact of Endothelial Microparticles on Coagulation, Inflammation, and Angiogenesis in Age-Related Vascular Diseases. Journal of Aging Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-494405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494405