The Effect of Intravenous Dexamethasone and Lidocaine on Propofol-Induced Vascular Pain : A Randomized Double-Blinded Placebo-Controlled Trial
Joint Authors
McCarthy, Robert J.
Ahmad, Shireen
De Oliveira, Gildasio S.
Fitzgerald, Paul C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The mechanism for pain associated with intravenous administration of propofol is believed to be related to the release of nitric oxide.
We hypothesized that pain following propofol injection would be reduced by pretreatment with dexamethasone.
Methods.
One hundred fourteen female subjects received 5 mL of preservative-free saline, 0.5 mg·kg−1 of lignocaine hydrochloride 10 mg·mL−1 or 0.25 mg·kg−1 of dexamethasone, intravenously, following exsanguination and occlusion of the veins of the arm.
This was followed by a 0.5 mg·kg−1 injection of propofol.
Pain scores, facial grimacing, arm withdrawal, and vocalization were recorded prior to and at 15 and 30 seconds following the injection of propofol.
Results.
The incidence of moderate to severe pain following the injection of propofol was significantly decreased with both lidocaine and dexamethasone.
Hand withdrawal was also significantly decreased in comparison to saline.
Conclusion.
Low dose dexamethasone is commonly used as an antiemetic, and, in larger doses, it has been demonstrated to provide prolonged postoperative analgesia.
At higher analgesic doses, dexamethasone may also reduce pain associated with the injection of propofol.
This effect is probably related to the effect of the steroid on nitric oxide production associated with intravenous propofol injection.
American Psychological Association (APA)
Ahmad, Shireen& De Oliveira, Gildasio S.& Fitzgerald, Paul C.& McCarthy, Robert J.. 2013. The Effect of Intravenous Dexamethasone and Lidocaine on Propofol-Induced Vascular Pain : A Randomized Double-Blinded Placebo-Controlled Trial. Pain Research and Treatment،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-494408
Modern Language Association (MLA)
Ahmad, Shireen…[et al.]. The Effect of Intravenous Dexamethasone and Lidocaine on Propofol-Induced Vascular Pain : A Randomized Double-Blinded Placebo-Controlled Trial. Pain Research and Treatment No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-494408
American Medical Association (AMA)
Ahmad, Shireen& De Oliveira, Gildasio S.& Fitzgerald, Paul C.& McCarthy, Robert J.. The Effect of Intravenous Dexamethasone and Lidocaine on Propofol-Induced Vascular Pain : A Randomized Double-Blinded Placebo-Controlled Trial. Pain Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-494408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494408