Nordihydroguaiaretic Acid from Creosote Bush (Larrea tridentata) Mitigates 12-O-Tetradecanoylphorbol-13-Acetate-Induced Inflammatory and Oxidative Stress Responses of Tumor Promotion Cascade in Mouse Skin
Joint Authors
Raisuddin, Sheikh
Ansari, Rizwan Ahmed
Rahman, Shakilur
Parvez, Suhel
Rehman, Hasibur
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc.
ex DC) Coville (creosote bush).
It has a long history of traditional medicinal use by the Native Americans and Mexicans.
The modulatory effects of topically applied NDGA was studied on acute inflammatory and oxidative stress responses in mouse skin induced by stage I tumor promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA).
Double TPA treatment adversely altered many of the marker responses of stage I skin tumor promotion cascade.
Pretreatment of NDGA in TPA-treated mice mitigated cutaneous lipid peroxidation and inhibited production of hydrogen peroxide.
NDGA treatment also restored reduced glutathione level and activities of antioxidant enzymes.
Elevated activities of myeloperoxidase, xanthine oxidase and skin edema formation in TPA-treated mice were also lowered by NDGA indicating a restrained inflammatory response.
Furthermore, results of histological study demonstrated inhibitory effect of NDGA on cellular inflammatory responses.
This study provides a direct evidence of antioxidative and anti-inflammatory properties of NDGA against TPA-induced cutaneous inflammation and oxidative stress corroborating its chemopreventive potential against skin cancer.
American Psychological Association (APA)
Rahman, Shakilur& Ansari, Rizwan Ahmed& Rehman, Hasibur& Parvez, Suhel& Raisuddin, Sheikh. 2011. Nordihydroguaiaretic Acid from Creosote Bush (Larrea tridentata) Mitigates 12-O-Tetradecanoylphorbol-13-Acetate-Induced Inflammatory and Oxidative Stress Responses of Tumor Promotion Cascade in Mouse Skin. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-494431
Modern Language Association (MLA)
Rahman, Shakilur…[et al.]. Nordihydroguaiaretic Acid from Creosote Bush (Larrea tridentata) Mitigates 12-O-Tetradecanoylphorbol-13-Acetate-Induced Inflammatory and Oxidative Stress Responses of Tumor Promotion Cascade in Mouse Skin. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-494431
American Medical Association (AMA)
Rahman, Shakilur& Ansari, Rizwan Ahmed& Rehman, Hasibur& Parvez, Suhel& Raisuddin, Sheikh. Nordihydroguaiaretic Acid from Creosote Bush (Larrea tridentata) Mitigates 12-O-Tetradecanoylphorbol-13-Acetate-Induced Inflammatory and Oxidative Stress Responses of Tumor Promotion Cascade in Mouse Skin. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-494431
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494431