Anti-Inflammatory, Anticholinesterase, and Antioxidant Potential of Scopoletin Isolated from Canarium patentinervium Miq. (Burseraceae Kunth)
Joint Authors
Teng-Jin, K.
Wiart, C.
Mogana, R.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Bioassay guided fractionation of an ethanol extract of leaves of Canarium patentinervium Miq.
(Burseraceae Kunth.) led to the isolation of scopoletin.
The structure of this coumarin was elucidated based on spectroscopic methods including nuclear magnetic resonance (NMR-1D and 2D) and mass spectrometry.
Scopoletin inhibited the enzymatic activity of 5-lipoxygenase and acetyl cholinesterase with an IC50 equal to 1.76±0.01 μM and 0.27±0.02 mM, respectively, and confronted oxidation in the ABTS, DPPH, FRAP, and β-carotene bleaching assay with EC50 values equal to 5.62±0.03 μM, 0.19±0.01 mM, 0.25±0.03 mM and 0.65±0.07 mM, respectively.
Given the aforementioned evidence, it is tempting to speculate that scopoletin represents an exciting scaffold from which to develop leads for treatment of neurodegenerative diseases.
American Psychological Association (APA)
Mogana, R.& Teng-Jin, K.& Wiart, C.. 2013. Anti-Inflammatory, Anticholinesterase, and Antioxidant Potential of Scopoletin Isolated from Canarium patentinervium Miq. (Burseraceae Kunth). Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-494433
Modern Language Association (MLA)
Mogana, R.…[et al.]. Anti-Inflammatory, Anticholinesterase, and Antioxidant Potential of Scopoletin Isolated from Canarium patentinervium Miq. (Burseraceae Kunth). Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-494433
American Medical Association (AMA)
Mogana, R.& Teng-Jin, K.& Wiart, C.. Anti-Inflammatory, Anticholinesterase, and Antioxidant Potential of Scopoletin Isolated from Canarium patentinervium Miq. (Burseraceae Kunth). Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-494433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494433