The Complexity of Sporadic Alzheimer’s Disease Pathogenesis : The Role of RAGE as Therapeutic Target to Promote Neuroprotection by Inhibiting Neurovascular Dysfunction
Joint Authors
Bierhaus, Angelika
Nawroth, Peter P.
Sbai, Oualid
Perrone, Lorena
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Alzheimer's disease (AD) is the most common cause of dementia.
Amyloid plaques and neurofibrillary tangles are prominent pathological features of AD.
Aging and age-dependent oxidative stress are the major nongenetic risk factors for AD.
The beta-amyloid peptide (Aβ), the major component of plaques, and advanced glycation end products (AGEs) are key activators of plaque-associated cellular dysfunction.
Aβ and AGEs bind to the receptor for AGEs (RAGE), which transmits the signal from RAGE via redox-sensitive pathways to nuclear factor kappa-B (NF-κB).
RAGE-mediated signaling is an important contributor to neurodegeneration in AD.
We will summarize the current knowledge and ongoing studies on RAGE function in AD.
We will also present evidence for a novel pathway induced by RAGE in AD, which leads to the expression of thioredoxin interacting protein (TXNIP), providing further evidence that pharmacological inhibition of RAGE will promote neuroprotection by blocking neurovascular dysfunction in AD.
American Psychological Association (APA)
Perrone, Lorena& Sbai, Oualid& Nawroth, Peter P.& Bierhaus, Angelika. 2012. The Complexity of Sporadic Alzheimer’s Disease Pathogenesis : The Role of RAGE as Therapeutic Target to Promote Neuroprotection by Inhibiting Neurovascular Dysfunction. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-494447
Modern Language Association (MLA)
Perrone, Lorena…[et al.]. The Complexity of Sporadic Alzheimer’s Disease Pathogenesis : The Role of RAGE as Therapeutic Target to Promote Neuroprotection by Inhibiting Neurovascular Dysfunction. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-494447
American Medical Association (AMA)
Perrone, Lorena& Sbai, Oualid& Nawroth, Peter P.& Bierhaus, Angelika. The Complexity of Sporadic Alzheimer’s Disease Pathogenesis : The Role of RAGE as Therapeutic Target to Promote Neuroprotection by Inhibiting Neurovascular Dysfunction. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-494447
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494447